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Bénédicte Pigneur
Researcher at Necker-Enfants Malades Hospital
Publications - 52
Citations - 5725
Bénédicte Pigneur is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Inflammatory bowel disease & Parenteral nutrition. The author has an hindex of 17, co-authored 44 publications receiving 4642 citations. Previous affiliations of Bénédicte Pigneur include Boston Children's Hospital & French Institute of Health and Medical Research.
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Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease
Elodie Quévrain,Marie-Anne Maubert,Christophe Michon,Florian Chain,Florian Chain,Rodrigue Marquant,Rodrigue Marquant,Rodrigue Marquant,Julien Tailhades,Julien Tailhades,Julien Tailhades,Sylvie Miquel,Sylvie Miquel,Ludovic Carlier,Ludovic Carlier,Ludovic Carlier,Luis G. Bermúdez-Humarán,Luis G. Bermúdez-Humarán,Bénédicte Pigneur,Bénédicte Pigneur,Olivier Lequin,Olivier Lequin,Olivier Lequin,Pascale Kharrat,Pascale Kharrat,Ginette Thomas,Ginette Thomas,Dominique Rainteau,Camille Aubry,Camille Aubry,N. Breyner,N. Breyner,Carlos Afonso,Solange Lavielle,Solange Lavielle,Solange Lavielle,Jean-Pierre Grill,Jean-Pierre Grill,Gérard Chassaing,Gérard Chassaing,Gérard Chassaing,Jean-Marc Chatel,Jean-Marc Chatel,Germain Trugnan,Ramnik J. Xavier,P. Langella,P. Langella,Harry Sokol,Philippe Seksik +48 more
TL;DR: A 15 kDa protein with anti-inflammatory properties is produced by F. prausnitzii, a commensal bacterium involved in CD pathogenesis, and is able to inhibit the NF-κB pathway in intestinal epithelial cells and to prevent colitis in an animal model.
Journal ArticleDOI
Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease
Bernadette Bègue,Julien Verdier,Frédéric Rieux-Laucat,Olivier Goulet,A. Morali,Danielle Canioni,Jean-Pierre Hugot,Cécile Daussy,Virginie Verkarre,Bénédicte Pigneur,Alain Fischer,Christoph Klein,Nadine Cerf-Bensussan,Frank M. Ruemmele +13 more
TL;DR: In this article, the capacities of transforming growth factor β (TGFβ) and IL10 to inhibit proinflammatory cytokine production by monocyte-derived dendritic cells (MoDC) or peripheral blood cells (PBMC) was analyzed in 75 children with IBD, including 13 infants with EO-IBD (in which autoimmune diseases or classical immunodeficiencies were ruled out).
Journal ArticleDOI
Natural history of Crohn's disease: Comparison between childhood‐ and adult‐onset disease
Bénédicte Pigneur,Philippe Seksik,S. Viola,Jérôme Viala,Laurent Beaugerie,Jean-Philippe Girardet,Frank M. Ruemmele,Jacques Cosnes +7 more
TL;DR: Patients with childhood‐onset Crohn's disease exhibit a more active disease and require more immunosuppressive therapy, suggesting an intrinsic more severe phenotype.
Journal ArticleDOI
The efficacy of exclusive nutritional therapy in paediatric Crohn’s disease, comparing fractionated oral vs. continuous enteral feeding
Amandine Rubio,Bénédicte Pigneur,Hélène Garnier-Lengliné,Cécile Talbotec,Jacques Schmitz,Danielle Canioni,Olivier Goulet,Frank M. Ruemmele +7 more
TL;DR: In this paper, the efficiency of exclusive nutrition to induce remission in children with Crohn’s disease comparing fractionated oral vs. continuous enteral feeding was analyzed. But, compliance is the main difficulty and may be greatly influenced by the administration route.