B
Bengt Sennblad
Researcher at Science for Life Laboratory
Publications - 82
Citations - 12462
Bengt Sennblad is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 40, co-authored 79 publications receiving 10488 citations. Previous affiliations of Bengt Sennblad include Stockholm University & Karolinska University Hospital.
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Journal ArticleDOI
Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Karl Gertow,Bengt Sennblad,Rona J. Strawbridge,John Öhrvik,Delilah Zabaneh,Sonia Shah,Fabrizio Veglia,Cristiano Fava,Maryam Kavousi,Stela McLachlan,Mika Kivimäki,Jennifer L. Bolton,Lasse Folkersen,Bruna Gigante,Karin Leander,Max Vikström,Malin Larsson,Angela Silveira,John E. Deanfield,Benjamin F. Voight,Pierre Fontanillas,Maria Sabater-Lleal,Gualtiero I. Colombo,Meena Kumari,Claudia Langenberg,Nicholas J. Wareham,André G. Uitterlinden,Anders Gabrielsen,Ulf Hedin,Anders Franco-Cereceda,Kristiina Nyyssönen,Rainer Rauramaa,Tomi-Pekka Tuomainen,Kai Savonen,Andries J. Smit,Philippe Giral,Elmo Mannarino,Christine Robertson,Philippa J. Talmud,Bo Hedblad,Albert Hofman,Jeanette Erdmann,Muredach P. Reilly,Christopher J. O'Donnell,Martin Farrall,Robert Clarke,Maria Grazia Franzosi,Udo Seedorf,Ann-Christine Syvänen,Göran K. Hansson,Per Eriksson,Nilesh J. Samani,Hugh Watkins,Jacqueline F. Price,Aroon D. Hingorani,Olle Melander,Jacqueline C. M. Witteman,Damiano Baldassarre,Elena Tremoli,Ulf de Faire,Steve E. Humphries,Anders Hamsten +61 more
TL;DR: This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent.
Journal ArticleDOI
Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin.
Shane McCarthy,Salim Mottagui-Tabar,Yumi Mizuno,Bengt Sennblad,Bengt Sennblad,Johan Hoffstedt,Peter Arner,Claes Wahlestedt,Björn Andersson +8 more
TL;DR: It is suggested that inconsistent associations between HTR2C and several phenotypes, including obesity, may be due to the LD pattern across the gene in which recombination and gene conversion have been influential.
Journal ArticleDOI
Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.
Bengt Sennblad,Bengt Sennblad,Saonli Basu,Johanna Mazur,Pierre Suchon,Angel Martinez-Perez,Astrid van Hylckama Vlieg,Vinh Truong,Yuhuang Li,Jesper R. Gådin,Weihong Tang,Vera Grossman,Hugoline G. de Haan,Niklas Handin,Angela Silveira,Juan Carlos Souto,Anders Franco-Cereceda,Pierre-Emmanuel Morange,José Manuel Soria,Per Eriksson,Anders Hamsten,Lars Maegdefessel,Frits R. Rosendaal,Philipp S. Wild,Aaron R. Folsom,David-Alexandre Trégouët,David-Alexandre Trégouët,Maria Sabater-Lleal +27 more
TL;DR: Conditional and haplotype analyses demonstrated a complex association signal, with additional novel SNPs modulating plasma FXI levels in both the F11 and KNG1 loci, which should open the door to new therapeutic targets for thrombosis prevention.
Journal ArticleDOI
Evaluation of Bayesian Models of Substitution Rate Evolution—Parental Guidance versus Mutual Independence
TL;DR: Under none of the models could be found compelling evidence, in any of the data sets, for rate correlation between adjacent branches/nodes, and these findings challenge previous suggestions of universality of autocorrelation in sequence evolution.
Journal ArticleDOI
Plasma IL-5 concentration and subclinical carotid atherosclerosis.
Angela Silveira,Olga McLeod,Rona J. Strawbridge,Karl Gertow,Bengt Sennblad,Bengt Sennblad,Damiano Baldassarre,Fabrizio Veglia,Anna Deleskog,Jonas Persson,Karin Leander,Bruna Gigante,Jussi Kauhanen,Rainer Rauramaa,Andries J. Smit,Elmo Mannarino,Philippe Giral,Sven A. Gustafsson,Stefan Söderberg,John Öhrvik,Steve E. Humphries,Elena Tremoli,Ulf de Faire,Anders Hamsten +23 more
TL;DR: The results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT).