B
Bengt Sennblad
Researcher at Science for Life Laboratory
Publications - 82
Citations - 12462
Bengt Sennblad is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 40, co-authored 79 publications receiving 10488 citations. Previous affiliations of Bengt Sennblad include Stockholm University & Karolinska University Hospital.
Papers
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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Jennifer Wessel,Audrey Y. Chu,Sara M. Willems,Shuai Wang,Hanieh Yaghootkar,Jennifer A. Brody,Marco Dauriz,Marie-France Hivert,Sridharan Raghavan,Leonard Lipovich,Bertha Hidalgo,Keolu Fox,Jennifer E. Huffman,Ping An,Yingchang Lu,Laura J. Rasmussen-Torvik,Niels Grarup,Margaret G. Ehm,Li Li,Abigail S. Baldridge,Alena Stančáková,Ravinder Abrol,Céline Besse,Anne Boland,Jette Bork-Jensen,Myriam Fornage,Daniel F. Freitag,Melissa E. Garcia,Xiuqing Guo,Hara Kazuo,Aaron Isaacs,Johanna Jakobsdottir,Leslie A. Lange,Jill Layton,Man Li,Jing Hua Zhao,Karina Meidtner,Alanna C. Morrison,Mike A. Nalls,Marjolein Peters,Maria Sabater-Lleal,Claudia Schurmann,Angela Silveira,Albert V. Smith,Lorraine Southam,Marcus H. Stoiber,Rona J. Strawbridge,Kent D. Taylor,Tibor V. Varga,Kristine H. Allin,Najaf Amin,Jennifer L. Aponte,Tin Aung,Caterina Barbieri,Nathan A. Bihlmeyer,Michael Boehnke,Cristina Bombieri,Donald W. Bowden,Sean M. Burns,Yuning Chen,Yii-DerI Chen,Ching-Yu Cheng,Adolfo Correa,Jacek Czajkowski,Abbas Dehghan,Georg Ehret,Gudny Eiriksdottir,Stefan A. Escher,Aliki-Eleni Farmaki,Mattias Frånberg,Giovanni Gambaro,Franco Giulianini,William A. Goddard,Anuj Goel,Omri Gottesman,Megan L. Grove,Stefan Gustafsson,Yang Hai,Göran Hallmans,Jiyoung Heo,Per Hoffmann,Mohammad Kamran Ikram,Richard A. Jensen,Marit E. Jørgensen,Torben Jørgensen,Maria Karaleftheri,Chiea Chuen Khor,Andrea Kirkpatrick,Aldi T. Kraja,Johanna Kuusisto,Ethan M. Lange,I-Te Lee,Wen-Jane Lee,Aaron Leong,Jiemin Liao,Chunyu Liu,Yongmei Liu,Cecilia M. Lindgren,Allan Linneberg,Giovanni Malerba,Vasiliki Mamakou,Eirini Marouli,Nisa M. Maruthur,Angela Matchan,Roberta McKean-Cowdin,Olga McLeod,Ginger A. Metcalf,Karen L. Mohlke,Donna M. Muzny,Ioanna Ntalla,Nicholette D. Palmer,Dorota Pasko,Andreas Peter,Nigel W. Rayner,Frida Renström,Kenneth Rice,Cinzia Sala,Bengt Sennblad,Ioannis Serafetinidis,Jennifer A. Smith,Nicole Soranzo,Elizabeth K. Speliotes,Eli A. Stahl,Kathleen Stirrups,Nikos Tentolouris,Anastasia Thanopoulou,Mina Torres,Michela Traglia,Emmanouil Tsafantakis,Sundas Javad,Lisa R. Yanek,Eleni Zengini,Diane M. Becker,Joshua C. Bis,James B. Brown,L. Adrienne Cupples,Torben Hansen,Erik Ingelsson,Andrew J. Karter,Carlos Lorenzo,Rasika A. Mathias,Jill M. Norris,Gina M. Peloso,Wayne Huey-Herng Sheu,Daniela Toniolo,Dhananjay Vaidya,Rohit Varma,Lynne E. Wagenknecht,Heiner Boeing,Erwin P. Bottinger,George Dedoussis,Panos Deloukas,Ele Ferrannini,Oscar H. Franco,Paul W. Franks,Richard A. Gibbs,Vilmundur Gudnason,Anders Hamsten,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Albert Hofman,Jan-Håkan Jansson,Claudia Langenberg,Lenore J. Launer,Daniel Levy,Ben A. Oostra,Christopher J. O'Donnell,Stephen O'Rahilly,Sandosh Padmanabhan,James S. Pankow,Ozren Polasek,Michael A. Province,Stephen S. Rich,Paul M. Ridker,Igor Rudan,Matthias B. Schulze,Blair H. Smith,André G. Uitterlinden,Mark Walker,Hugh Watkins,Tien Yin Wong,Eleftheria Zeggini,Markku Laakso,Ingrid B. Borecki,Daniel I. Chasman,Oluf Pedersen,Bruce M. Psaty,E. Shyong Tai,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Eric Boerwinkle,W. H. Linda Kao,Jose C. Florez,Ruth J. F. Loos,James G. Wilson,Timothy M. Frayling,David S. Siscovick,Josée Dupuis,Jerome I. Rotter,James B. Meigs,Robert A. Scott,Mark O. Goodarzi +203 more
TL;DR: The approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
Journal ArticleDOI
A Bayesian method for analyzing lateral gene transfer.
Joel Sjöstrand,Joel Sjöstrand,Ali Tofigh,Vincent Daubin,Lars Arvestad,Lars Arvestad,Bengt Sennblad,Bengt Sennblad,Jens Lagergren,Jens Lagergren +9 more
TL;DR: A Bayesian Markov-chain Monte Carlo-based method is presented that integrates GD, gene loss, LGT, and sequence evolution, and is applied in a genome-wide analysis of two groups of bacteria: Mollicutes and Cyanobacteria.
Journal ArticleDOI
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
Jie Huang,Maria Sabater-Lleal,Folkert W. Asselbergs,David-Alexandre Trégouët,So-Youn Shin,Jingzhong Ding,Jens Baumert,Tiphaine Oudot-Mellakh,Lasse Folkersen,Andrew D. Johnson,Nicholas L. Smith,Scott M. Williams,Mohammad Arfan Ikram,Marcus E. Kleber,Diane M. Becker,Vinh Truong,Josyf C. Mychaleckyj,Weihong Tang,Qiong Yang,Bengt Sennblad,Jason H. Moore,Frances M K Williams,Abbas Dehghan,Günther Silbernagel,Elisabeth M. C. Schrijvers,Shelly G. Smith,Mahir Karakas,Geoffrey H. Tofler,Angela Silveira,Gerjan Navis,Kurt Lohman,Ming-Huei Chen,Annette Peters,Anuj Goel,Jemma C. Hopewell,John C. Chambers,Danish Saleheen,Per Lundmark,Bruce M. Psaty,Rona J. Strawbridge,Bernhard O. Boehm,Angela M. Carter,Christa Meisinger,John F. Peden,Joshua C. Bis,Barbara McKnight,John Öhrvik,Kent D. Taylor,Maria Grazia Franzosi,Udo Seedorf,Rory Collins,Anders Franco-Cereceda,Ann-Christine Syvänen,Alison H. Goodall,Lisa R. Yanek,Mary Cushman,Martina Müller-Nurasyid,Aaron R. Folsom,Saonli Basu,Nena Matijevic,Wiek H. van Gilst,Jaspal S. Kooner,Albert Hofman,John Danesh,Robert Clarke,James B. Meigs,Sekar Kathiresan,Muredach P. Reilly,Norman Klopp,Tamara B. Harris,Bernhard R. Winkelmann,Peter J. Grant,Hans L. Hillege,Hugh Watkins,Tim D. Spector,Lewis C. Becker,Russell P. Tracy,Winfried März,André G. Uitterlinden,Per Eriksson,François Cambien,Pierre-Emmanuel Morange,Wolfgang Koenig,Nicole Soranzo,Pim van der Harst,Yongmei Liu,Christopher J. O'Donnell,Anders Hamsten +87 more
TL;DR: SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1.
Journal ArticleDOI
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Paul S. de Vries,Daniel I. Chasman,Daniel I. Chasman,Maria Sabater-Lleal,Ming-Huei Chen,Jennifer E. Huffman,Maristella Steri,Weihong Tang,Alexander Teumer,Riccardo E. Marioni,Vera Grossmann,Jouke J. Hottenga,Stella Trompet,Martina Müller-Nurasyid,Jing Hua Zhao,Jennifer A. Brody,Marcus E. Kleber,Xiuqing Guo,Jie Jin Wang,Paul L. Auer,John Attia,Lisa R. Yanek,Tarunveer S. Ahluwalia,Jari Lahti,Cristina Venturini,Toshiko Tanaka,Lawrence F. Bielak,Peter K. Joshi,Ares Rocanin-Arjo,Ivana Kolcic,Pau Navarro,Lynda M. Rose,Christopher Oldmeadow,Helene Riess,Johanna Mazur,Saonli Basu,Anuj Goel,Qiong Yang,Mohsen Ghanbari,Gonneke Willemsen,Ann Rumley,Edoardo Fiorillo,Anton J. M. de Craen,Anne Grotevendt,Robert A. Scott,Kent D. Taylor,Graciela E. Delgado,Jie Yao,Annette Kifley,Charles Kooperberg,Rehan Qayyum,Lorna M. Lopez,Lorna M. Lopez,Tina L. Berentzen,Katri Räikkönen,Massimo Mangino,Stefania Bandinelli,Patricia A. Peyser,Sarah H. Wild,David-Alexandre Trégouët,Alan F. Wright,Jonathan Marten,Tatijana Zemunik,Alanna C. Morrison,Bengt Sennblad,Geoffrey H. Tofler,Moniek P.M. de Maat,Eco J. C. de Geus,Gordon D.O. Lowe,Magdalena Zoledziewska,Naveed Sattar,Harald Binder,Uwe Völker,Melanie Waldenberger,Kay-Tee Khaw,Barbara McKnight,Jie Huang,Nancy S. Jenny,Elizabeth G. Holliday,Lihong Qi,Mark G. Mcevoy,Diane M. Becker,John M. Starr,Antti-Pekka Sarin,Antti-Pekka Sarin,Pirro G. Hysi,Dena G. Hernandez,Min A. Jhun,Harry Campbell,Anders Hamsten,Fernando Rivadeneira,Wendy L. McArdle,P. Eline Slagboom,Tanja Zeller,Wolfgang Koenig,Bruce M. Psaty,Talin Haritunians,Jingmin Liu,Aarno Palotie,André G. Uitterlinden,David J. Stott,Albert Hofman,Oscar H. Franco,Ozren Polasek,Igor Rudan,Pierre-Emmanuel Morange,James F. Wilson,Sharon L.R. Kardia,Luigi Ferrucci,Tim D. Spector,Johan G. Eriksson,Torben Hansen,Ian J. Deary,Lewis C. Becker,Rodney J. Scott,Paul Mitchell,Winfried März,Nicholas J. Wareham,Annette Peters,Andreas Greinacher,Philipp S. Wild,J. Wouter Jukema,Dorret I. Boomsma,Caroline Hayward,Francesco Cucca,Russell P. Tracy,Hugh Watkins,Alexander P. Reiner,Aaron R. Folsom,Paul M. Ridker,Paul M. Ridker,Christopher J. O'Donnell,Nicholas L. Smith,David P. Strachan,Abbas Dehghan +134 more
TL;DR: A genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry identified 41 genome- wide significant fibrinogen loci; of which, 18 were newly identified.
Journal ArticleDOI
Associations of autozygosity with a broad range of human phenotypes
David W. Clark,Yukinori Okada,Kristjan H. S. Moore,Dan Mason,Nicola Pirastu,Ilaria Gandin,Ilaria Gandin,Hannele Mattsson,Hannele Mattsson,Catriona L. K. Barnes,Kuang Lin,Jing Hua Zhao,Patrick Deelen,Rebecca Rohde,Claudia Schurmann,Xiuqing Guo,Franco Giulianini,Weihua Zhang,Weihua Zhang,Carolina Medina-Gomez,Robert Karlsson,Yanchun Bao,Traci M. Bartz,Clemens Baumbach,Ginevra Biino,Matthew J. Bixley,Marco Brumat,Jin-Fang Chai,Tanguy Corre,Tanguy Corre,Diana L. Cousminer,Annelot M. Dekker,David Eccles,David Eccles,Kristel R van Eijk,Christian Fuchsberger,He Gao,Marine Germain,Marine Germain,Scott D. Gordon,Hugoline G. de Haan,Sarah E. Harris,Edith Hofer,Alicia Huerta-Chagoya,Catherine Igartua,Iris E. Jansen,Iris E. Jansen,Yucheng Jia,Tim Kacprowski,Tim Kacprowski,Torgny Karlsson,Marcus E. Kleber,Shengchao Alfred Li,Ruifang Li-Gao,Anubha Mahajan,Koichi Matsuda,Karina Meidtner,Weihua Meng,May E. Montasser,Peter J. van der Most,Matthias Munz,Teresa Nutile,Teemu Palviainen,Gauri Prasad,Rashmi B. Prasad,Tallapragada Divya Sri Priyanka,Federica Rizzi,Erika Salvi,Erika Salvi,Bishwa Raj Sapkota,Daniel Shriner,Line Skotte,Melissa C. Smart,Albert V. Smith,Ashley van der Spek,Cassandra N. Spracklen,Rona J. Strawbridge,Rona J. Strawbridge,Salman M. Tajuddin,Stella Trompet,Constance Turman,Niek Verweij,Clara Viberti,Lihua Wang,Helen R. Warren,Robyn E Wootton,Lisa R. Yanek,Jie Yao,Noha A. Yousri,Noha A. Yousri,Wei Zhao,Adebowale Adeyemo,Saima Afaq,Carlos A. Aguilar-Salinas,Masato Akiyama,Matthew L. Albert,Matthew A. Allison,Maris Alver,Tin Aung,Fereidoun Azizi,Amy R. Bentley,Heiner Boeing,Eric Boerwinkle,Judith B. Borja,Gert J. de Borst,Erwin P. Bottinger,Erwin P. Bottinger,Linda Broer,Harry Campbell,Stephen J. Chanock,Miao-Li Chee,Guanjie Chen,Yii-Der Ida Chen,Zhengming Chen,Yen-Feng Chiu,Massimiliano Cocca,Francis S. Collins,Maria Pina Concas,Janie Corley,Giovanni Cugliari,Rob M. van Dam,Rob M. van Dam,Anna Damulina,Maryam S. Daneshpour,Felix R. Day,Graciela E. Delgado,Klodian Dhana,Klodian Dhana,Klodian Dhana,Alex S. F. Doney,Marcus Dörr,Ayo P. Doumatey,Nduna Dzimiri,S. Sunna Ebenesersdóttir,S. Sunna Ebenesersdóttir,Joshua Elliott,Paul Elliott,Ralf Ewert,Janine F. Felix,Krista Fischer,Barry I. Freedman,Giorgia Girotto,Anuj Goel,Martin Gögele,Mark O. Goodarzi,Mariaelisa Graff,Einat Granot-Hershkovitz,Francine Grodstein,Simonetta Guarrera,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Kamran Guity,Bjarni Gunnarsson,Yu Guo,Saskia P. Hagenaars,Saskia P. Hagenaars,Christopher A. Haiman,Avner Halevy,Tamara B. Harris,Mehdi Hedayati,David A. van Heel,Makoto Hirata,Imo Hofer,Chao A. Hsiung,Jinyan Huang,Yi-Jen Hung,Yi-Jen Hung,M. Arfan Ikram,Anuradha Jagadeesan,Anuradha Jagadeesan,Pekka Jousilahti,Yoichiro Kamatani,Masahiro Kanai,Masahiro Kanai,Nicola D. Kerrison,Thorsten Kessler,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Dominique P.V. de Kleijn,Woon-Puay Koh,Ivana Kolcic,Peter Kraft,Bernhard K. Krämer,Zoltán Kutalik,Zoltán Kutalik,Johanna Kuusisto,Claudia Langenberg,Lenore J. Launer,Debbie A Lawlor,I-Te Lee,I-Te Lee,Wen-Jane Lee,Markus M. Lerch,Liming Li,Jianjun Liu,Jianjun Liu,Marie Loh,Marie Loh,Marie Loh,Stephanie J. London,Stephanie J. Loomis,Yingchang Lu,Jian'an Luan,Reedik Mägi,Ani Manichaikul,Paolo Manunta,Gisli Masson,Nana Matoba,Xue W. Mei,Christa Meisinger,Thomas Meitinger,Massimo Mezzavilla,Lili Milani,Iona Y Millwood,Yukihide Momozawa,Amy Moore,Pierre-Emmanuel Morange,Hortensia Moreno-Macías,Trevor A. Mori,Alanna C. Morrison,Taulant Muka,Taulant Muka,Yoshinori Murakami,Alison D. Murray,Renée de Mutsert,Josyf C. Mychaleckyj,Mike A. Nalls,Matthias Nauck,Matt J. Neville,Matt J. Neville,Ilja M. Nolte,Ken K. Ong,Lorena Orozco,Sandosh Padmanabhan,Gunnar K. Pálsson,James S. Pankow,Cristian Pattaro,Alison Pattie,Ozren Polasek,Neil Poulter,Peter P. Pramstaller,Lluis Quintana-Murci,Lluis Quintana-Murci,Katri Räikkönen,Sarju Ralhan,Dabeeru C. Rao,Wouter van Rheenen,Stephen S. Rich,Paul M. Ridker,Paul M. Ridker,Cornelius A. Rietveld,Antonietta Robino,Frank J. A. van Rooij,Daniela Ruggiero,Yasaman Saba,Charumathi Sabanayagam,Maria Sabater-Lleal,Cinzia Sala,Veikko Salomaa,Kevin Sandow,Helena Schmidt,Laura J. Scott,William R. Scott,Bahareh Sedaghati-khayat,Bengt Sennblad,Bengt Sennblad,Jessica van Setten,Peter S. Sever,Wayne Huey-Herng Sheu,Yuan Shi,Smeeta Shrestha,Smeeta Shrestha,Sharvari Rahul Shukla,Jon K. Sigurdsson,Timo Tõnis Sikka,Jai Rup Singh,Blair H. Smith,Alena Stančáková,Alice Stanton,John M. Starr,Lilja Stefansdottir,Leon Straker,Patrick Sulem,Gardar Sveinbjornsson,Morris A. Swertz,Adele M. Taylor,Kent D. Taylor,Natalie Terzikhan,Natalie Terzikhan,Yih Chung Tham,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Annika Tillander,Russell P. Tracy,Teresa Tusié-Luna,Ioanna Tzoulaki,Ioanna Tzoulaki,Simona Vaccargiu,Jagadish Vangipurapu,Jan H. Veldink,Veronique Vitart,Uwe Völker,Eero Vuoksimaa,Salma M. Wakil,Melanie Waldenberger,Gurpreet Singh Wander,Ya Xing Wang,Nicholas J. Wareham,Sarah H. Wild,Chittaranjan S. Yajnik,Jian-Min Yuan,Lingyao Zeng,Liang Zhang,Jie Zhou,Najaf Amin,Folkert W. Asselbergs,Stephan J. L. Bakker,Diane M. Becker,Benjamin Lehne,David A. Bennett,Leonard H. van den Berg,Sonja I. Berndt,Dwaipayan Bharadwaj,Lawrence F. Bielak,Murielle Bochud,Michael Boehnke,Claude Bouchard,Jonathan P. Bradfield,Jennifer A. Brody,Archie Campbell,Shai Carmi,Mark J. Caulfield,David Cesarini,John C. Chambers,Giriraj R. Chandak,Ching-Yu Cheng,Marina Ciullo,Marilyn C. Cornelis,Daniele Cusi,Daniele Cusi,George Davey Smith,Ian J. Deary,Rajkumar Dorajoo,Cornelia M. van Duijn,Cornelia M. van Duijn,David Ellinghaus,Jeanette Erdmann,Johan G. Eriksson,Evangelos Evangelou,Evangelos Evangelou,Michele K. Evans,Jessica D. Faul,Bjarke Feenstra,Mary F. Feitosa,Sylvain Foisy,Andre Franke,Yechiel Friedlander,Paolo Gasparini,Christian Gieger,Clicerio Gonzalez,Philippe Goyette,Struan F.A. Grant,Lyn R. Griffiths,Leif Groop,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Hakon Hakonarson,Anders Hamsten,Pim van der Harst,Chew-Kiat Heng,Chew-Kiat Heng,Andrew A. Hicks,Hagit Hochner,Heikki V. Huikuri,Steven C. Hunt,Steven C. Hunt,Vincent W. V. Jaddoe,Philip L. De Jager,Philip L. De Jager,Magnus Johannesson,Åsa Johansson,Jost B. Jonas,Jost B. Jonas,J. Wouter Jukema,Juhani Junttila,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Fredrik Karpe,Meena Kumari,Markku Laakso,Sander W. van der Laan,Jari Lahti,Matthias Laudes,Rodney A. Lea,Wolfgang Lieb,Thomas Lumley,Nicholas G. Martin,Winfried März,Winfried März,Giuseppe Matullo,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Sarah E. Medland,Tony R. Merriman,Andres Metspalu,Brian F. Meyer,Karen L. Mohlke,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Patricia B. Munroe,Kari E. North,Dale R. Nyholt,Dale R. Nyholt,Jeffery R. O'Connell,Carole Ober,Albertine J. Oldehinkel,Walter Palmas,Colin N. A. Palmer,Gerard Pasterkamp,Etienne Patin,Etienne Patin,Craig E. Pennell,Craig E. Pennell,Louis Pérusse,Patricia A. Peyser,Mario Pirastu,Tinca J. C. Polderman,David J. Porteous,Danielle Posthuma,Bruce M. Psaty,Bruce M. Psaty,John D. Rioux,John D. Rioux,Fernando Rivadeneira,Charles N. Rotimi,Jerome I. Rotter,Igor Rudan,Hester M. den Ruijter,Dharambir K. Sanghera,Naveed Sattar,Reinhold Schmidt,Matthias B. Schulze,Heribert Schunkert,Robert A. Scott,Alan R. Shuldiner,Alan R. Shuldiner,Xueling Sim,Neil Small,Jennifer A. Smith,Nona Sotoodehnia,E-Shyong Tai,Alexander Teumer,Nicholas J. Timpson,Daniela Toniolo,David-Alexandre Trégouët,Tiinamaija Tuomi,Peter Vollenweider,Carol A. Wang,Carol A. Wang,David R. Weir,John Whitfield,Cisca Wijmenga,Tien Yin Wong,John Wright,Jingyun Yang,Lei Yu,Babette S. Zemel,Alan B. Zonderman,Markus Perola,Patrik K. E. Magnusson,André G. Uitterlinden,Jaspal S. Kooner,Daniel I. Chasman,Daniel I. Chasman,Ruth J. F. Loos,Ruth J. F. Loos,Nora Franceschini,Lude Franke,Chris Haley,Caroline Hayward,Robin G. Walters,John R. B. Perry,T Esko,T Esko,Agnar Helgason,Agnar Helgason,Kari Stefansson,Kari Stefansson,Peter K. Joshi,Michiaki Kubo,James F. Wilson +496 more
TL;DR: In this paper, the authors used genomic inbreeding coefficients (FROH) for >1.4 million individuals and found that FROH is significantly associated with apparently deleterious changes in 32 out of 100 traits analysed.