B
Bente Klarlund Pedersen
Researcher at University of Copenhagen
Publications - 713
Citations - 81605
Bente Klarlund Pedersen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Skeletal muscle & Insulin resistance. The author has an hindex of 134, co-authored 689 publications receiving 72177 citations. Previous affiliations of Bente Klarlund Pedersen include Health Science University & University of Copenhagen Faculty of Health Sciences.
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Journal ArticleDOI
Muscle-derived interleukin-6: possible biological effects.
TL;DR: Muscle‐derived IL‐6 is released into the circulation during exercise in high amounts and is likely to work in a hormone‐like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise‐induced lipolysis.
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The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk.
TL;DR: The finding that muscles produce and release myokines provides a conceptual basis to understand the mechanisms whereby exercise influences metabolism and exerts anti‐inflammatory effects.
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Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution
Line Pedersen,Manja Idorn,Gitte Holmen Olofsson,Britt Lauenborg,Intawat Nookaew,Intawat Nookaew,Rasmus Hvass Hansen,Helle Hjorth Johannesen,Jürgen C. Becker,Katrine S. Pedersen,Christine Dethlefsen,Jens Nielsen,Julie Gehl,Bente Klarlund Pedersen,Per thor Straten,Per thor Straten,Pernille Hojman,Pernille Hojman +17 more
TL;DR: Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of β-adrenergic signaling blunted training-dependent tumor inhibition, and IL-6-blocking antibodies bluned training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation.
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Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
TL;DR: Paradoxically, deleterious actions for IL‐6 have also been proposed, such as promotion of atrophy and muscle wasting, and the current evidence for these apparently contradictory effects is reviewed.
Journal ArticleDOI
Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content
Charlotte Keller,Adam Steensberg,Henriette Pilegaard,Takuya Osada,Bengt Saltin,Bente Klarlund Pedersen,P. Darrell Neufer +6 more
TL;DR: The data demonstrate that exercise activates transcription of the IL‐6 gene in working skeletal muscle, a response that is dramatically enhanced when glycogen levels are low, and support the hypothesis that IL‐ 6 may be produced by contracting myofibers when glycogens levels become critically low as a means of signaling the liver to increase glucose production.