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Bernard E. Ebruke
Researcher at Medical Research Council
Publications - 42
Citations - 3290
Bernard E. Ebruke is an academic researcher from Medical Research Council. The author has contributed to research in topics: Pneumonia & Medicine. The author has an hindex of 20, co-authored 37 publications receiving 2207 citations. Previous affiliations of Bernard E. Ebruke include University of London.
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Journal ArticleDOI
Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study
Daniel R. Feikin,Wei Fu,Daniel E. Park,Daniel E. Park,Qiyuan Shi,Melissa M. Higdon,Henry C. Baggett,Brooks Wa,Deloria Knoll M,Laura L. Hammitt,Laura L. Hammitt,Howie Src,Karen L. Kotloff,Orin S. Levine,Orin S. Levine,Shabir A. Madhi,Scott Jag.,Donald M. Thea,Peter V. Adrian,Peter V. Adrian,Martin Antonio,Martin Antonio,Martin Antonio,Juliet O. Awori,Vicky L. Baillie,Vicky L. Baillie,Andrea DeLuca,Amanda J. Driscoll,Bernard E. Ebruke,Doli Goswami,Ruth A. Karron,Mengying Li,Susan C. Morpeth,Susan C. Morpeth,Susan C. Morpeth,John Mwaba,James Mwansa,Christine Prosperi,Pongpun Sawatwong,Samba O. Sow,Tapia,Toni Whistler,K. Zaman,Scott L. Zeger,O' Brien Kl,David R. Murdoch +45 more
TL;DR: Although higher viral loads among pneumonia cases than controls for some viruses are found, the utility in using viral load of URT specimens to define viral pneumonia was equivocal and analysis was limited by lack of a gold standard for viral pneumonia.
Journal ArticleDOI
Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study
Melissa M. Higdon,Tham T Le,Tham T Le,Katherine L. O'Brien,David R. Murdoch,David R. Murdoch,Christine Prosperi,Henry C. Baggett,W. Abdullah Brooks,W. Abdullah Brooks,Daniel R. Feikin,Daniel R. Feikin,Laura L. Hammitt,Laura L. Hammitt,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Karen L. Kotloff,Orin S. Levine,Orin S. Levine,J. Anthony G. Scott,J. Anthony G. Scott,Donald M. Thea,Juliet O. Awori,Vicky L. Baillie,Vicky L. Baillie,Stephanie Cascio,Somchai Chuananon,Andrea DeLuca,Amanda J. Driscoll,Bernard E. Ebruke,Hubert P. Endtz,Hubert P. Endtz,Anek Kaewpan,Geoff Kahn,Angela Karani,Ruth A. Karron,David P. Moore,David P. Moore,Daniel E. Park,Daniel E. Park,Mohammed Ziaur Rahman,Rasheed Salaudeen,Rasheed Salaudeen,Phil Seidenberg,Phil Seidenberg,Somwe Wa Somwe,Mamadou Sylla,Milagritos D. Tapia,Scott L. Zeger,Maria Deloria Knoll,Shabir A. Madhi,Shabir A. Madhi,Nicholas Fancourt,Wei Fu,E Wangeci Kagucia,Mengying Li,Zhenke Wu,Nora L. Watson,Jane Crawley,Khalequ Zaman,Doli Goswami,Lokman Hossain,Yasmin Jahan,Hasan Ashraf,Martin Antonio,Jessica McLellan,Eunice M. Machuka,Arifin Shamsul,Syed M. A. Zaman,Grant A. Mackenzie,Susan C. Morpeth,Alice Kamau,Sidi Kazungu,Micah Silaba Ominde,Samba O. Sow,Boubou Tamboura,Uma Onwuchekwa,Nana Kourouma,Aliou Toure,Peter V. Adrian,Locadiah Kuwanda,Azwifarwi Mudau,Michelle J. Groome,Nasreen Mahomed,Somsak Thamthitiwat,Susan A. Maloney,Charatdao Bunthi,Julia Rhodes,Pongpun Sawatwong,Pasakorn Akarasewi,Lawrence Mwananyanda,James Chipeta,James Mwansa,Geoffrey Kwenda,Trevor P. Anderson,Joanne L. Mitchell +96 more
TL;DR: Elevated CRP was positively associated with confirmed bacterial pneumonia and negatively associated with RSV pneumonia in PERCH, suggesting CRP may be useful for distinguishing bacterial from RSV-associated pneumonia, although its role in discriminating against other respiratory viral- associated pneumonia needs further study.
Journal ArticleDOI
The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia
Amanda J. Driscoll,Deloria Knoll M,Laura L. Hammitt,Laura L. Hammitt,Henry C. Baggett,Brooks Wa,Daniel R. Feikin,Daniel R. Feikin,Karen L. Kotloff,Orin S. Levine,Orin S. Levine,Shabir A. Madhi,Katherine L O'Brien,Scott Jag.,Donald M. Thea,Howie Src,Peter V. Adrian,Peter V. Adrian,Dilruba Ahmed,Andrea DeLuca,Bernard E. Ebruke,Caroline W. Gitahi,Melissa M. Higdon,Anek Kaewpan,Angela Karani,Ruth A. Karron,Razib Mazumder,Jessica McLellan,Jessica McLellan,David P. Moore,David P. Moore,Lawrence Mwananyanda,Lawrence Mwananyanda,Daniel E. Park,Daniel E. Park,Christine Prosperi,Julia Rhodes,Muhammad Saifullah,Phil Seidenberg,Phil Seidenberg,Samba O. Sow,Boubou Tamboura,Scott L. Zeger,David R. Murdoch +43 more
TL;DR: Antibiotic exposure and blood culture volume affect detection of bacterial pathogens in children with pneumonia and should be accounted for in studies of etiology and in clinical management.
Journal ArticleDOI
Standardized interpretation of chest radiographs in cases of pediatric pneumonia from the PERCH study
Nicholas Fancourt,Nicholas Fancourt,Maria Deloria Knoll,Breanna Barger-Kamate,John de Campo,Margaret de Campo,Mahamadou Diallo,Bernard E. Ebruke,Daniel R. Feikin,Daniel R. Feikin,Fergus V. Gleeson,Wenfeng Gong,Laura L. Hammitt,Laura L. Hammitt,Rasa Izadnegahdar,Anchalee Kruatrachue,Shabir A. Madhi,Shabir A. Madhi,Veronica Manduku,Fariha Bushra Matin,Nasreen Mahomed,David P. Moore,David P. Moore,Musaku Mwenechanya,Kamrun Nahar,Claire Oluwalana,Micah Silaba Ominde,Christine Prosperi,Joyce Sande,Piyarat Suntarattiwong,Katherine L. O'Brien +30 more
TL;DR: The Pneumonia Etiology Research for Child Health (PERCH) study enrolled children aged 1-59 months hospitalized with severe and very severe pneumonia from 7 low-and middle-income countries.
Journal ArticleDOI
Safety of Induced Sputum Collection in Children Hospitalized With Severe or Very Severe Pneumonia.
Andrea DeLuca,Laura L. Hammitt,Julia M. Kim,Melissa M. Higdon,Henry C. Baggett,W. Abdullah Brooks,Stephen R. C. Howie,Maria Deloria Knoll,Karen L. Kotloff,Orin S. Levine,Shabir A. Madhi,David R. Murdoch,J. Anthony G. Scott,Donald M. Thea,Tussanee Amornintapichet,Juliet O. Awori,Somchai Chuananon,Amanda J. Driscoll,Bernard E. Ebruke,Lokman Hossain,Yasmin Jahan,E Wangeci Kagucia,Sidi Kazungu,David P. Moore,Azwifarwi Mudau,Lawrence Mwananyanda,Daniel E. Park,Christine Prosperi,Phil Seidenberg,Mamadou Sylla,Milagritos D. Tapia,Syed M. A. Zaman,Katherine L O'Brien +32 more
TL;DR: The overall frequency of IS procedures was very low, and the nature of most SAEs was manageable, demonstrating a low-risk safety profile for IS collection even among severely ill children in low-income-country settings.