J
Jennifer O'Neil
Researcher at Merck & Co.
Publications - 43
Citations - 4227
Jennifer O'Neil is an academic researcher from Merck & Co.. The author has contributed to research in topics: Notch signaling pathway & Promoter. The author has an hindex of 20, co-authored 39 publications receiving 3922 citations. Previous affiliations of Jennifer O'Neil include Harvard University & University of Massachusetts Medical School.
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Journal ArticleDOI
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
Teresa Palomero,Wei Keat Lim,Duncan T. Odom,Maria Luisa Sulis,Pedro J. Real,Adam A. Margolin,Kelly Barnes,Jennifer O'Neil,Donna Neuberg,Andrew P. Weng,Jon C. Aster,François Sigaux,Jean Soulier,A. Thomas Look,Richard A. Young,Andrea Califano,Adolfo A. Ferrando +16 more
TL;DR: In this paper, the authors used an integrative systems biology approach to identify c-myc as an essential mediator of NOTCH1 signaling and integrate NOTCH 1 activation with oncogenic signaling pathways upstream of c-MYC.
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
Jennifer O'Neil,Jonathan E. Grim,Peter Strack,Sudhir Rao,Deanne Tibbitts,Christopher Winter,James S. Hardwick,Markus Welcker,Jules P.P. Meijerink,Rob Pieters,Giulio Draetta,Rosalie C. Sears,Bruce E. Clurman,A. Thomas Look +13 more
TL;DR: It is shown that all seven leukemic cell lines with FBW7 mutations were resistant to the MRK-003 GSI and most of these resistant lines also failed to down-regulate the mRNA levels of the NOTCH targets MYC and DELTEX1 after treatment with MRk-003, implying that residual NOTCH signaling in T-ALLs with FBw7 mutations contributes to GSI resistance.
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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser,Bhudipa Choudhury,Peter J. Campbell,Bin Feng,Kwok-Kin Wong,Alexei Protopopov,Jennifer O'Neil,Alejandro Gutierrez,Elena Ivanova,Ilana Perna,Eric Lin,Vidya Mani,Shan Jiang,Kate McNamara,Sara Zaghlul,Sarah Edkins,Claire Stevens,Cameron Brennan,Eric S. Martin,Ruprecht Wiedemeyer,Omar Kabbarah,Cristina W. Nogueira,Gavin Histen,Jon C. Aster,Marc R. Mansour,Veronique Duke,Letizia Foroni,Adele K. Fielding,Anthony H. Goldstone,Jacob M. Rowe,Yaoqi A. Wang,A. Thomas Look,Michael R. Stratton,Lynda Chin,P. Andrew Futreal,Ronald A. DePinho +35 more
TL;DR: The results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution.
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Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
TL;DR: Daxx is a novel nuclear protein bearing transcriptional repressor activity that may be regulated by interaction with PML, and SUMO-1 modification of PML is required for sequestration of Daxx to the PODs and for efficient inhibition of DAXx-mediated transcriptional repression.
Journal ArticleDOI
Activating Notch1 mutations in mouse models of T-ALL.
Jennifer O'Neil,Jennifer A. Calvo,Keith McKenna,Veena Krishnamoorthy,Jon C. Aster,Craig H. Bassing,Craig H. Bassing,Frederick W. Alt,Frederick W. Alt,Michelle A. Kelliher,A. Thomas Look +10 more
TL;DR: The heterodimerization domain and the PEST domain of Notch1 are sequenced in the mouse model of TAL1-induced leukemia and it is found that 74% of the tumors harbor activating mutations in NotCh1.