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Bipul R. Acharya
Researcher at University of Queensland
Publications - 28
Citations - 1022
Bipul R. Acharya is an academic researcher from University of Queensland. The author has contributed to research in topics: Adherens junction & Cadherin. The author has an hindex of 13, co-authored 24 publications receiving 802 citations. Previous affiliations of Bipul R. Acharya include University of Calcutta & Cornell University.
Papers
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Journal ArticleDOI
Remodeling the zonula adherens in response to tension and the role of afadin in this response
Wangsun Choi,Bipul R. Acharya,Grégoire Peyret,Marc-Antoine Fardin,René-Marc Mège,Benoit Ladoux,Benoit Ladoux,Alpha S. Yap,Alan S. Fanning,Mark Peifer +9 more
TL;DR: Key roles for zonula occludens family proteins in regulating contractility and for the scaffolding protein afadin in maintaining ZA architecture at tricellular junctions are defined.
Journal ArticleDOI
A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress
Bipul R. Acharya,Alexander Nestor-Bergmann,Xuan Liang,Shafali Gupta,Kinga Duszyc,Estelle Gauquelin,Guillermo A. Gomez,Srikanth Budnar,Philippe Marcq,Oliver E. Jensen,Zev Bryant,Alpha S. Yap +11 more
TL;DR: A mechanosensitive signaling pathway that activates RhoA at adherens junctions to preserve epithelial integrity in response to acute tensile stress is reported.
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Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions
Magdalene Michael,Magdalene Michael,Joyce C.M. Meiring,Bipul R. Acharya,Daniel R. Matthews,Suzie Verma,Siew Ping Han,Michelle M. Hill,Robert G. Parton,Guillermo A. Gomez,Alpha S. Yap +10 more
TL;DR: It is proposed that contractile stress transmitted from the apoptotic cell through E-cadherin adhesions elicits a mechanosensitive response in neighbor cells that is necessary for the morphogenetic event of apoptotic extrusion to occur.
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Mammalian diaphanous 1 mediates a pathway for E-cadherin to stabilize epithelial barriers through junctional contractility
Bipul R. Acharya,Selwin K. Wu,Zi Zhao Lieu,Robert G. Parton,Stephan W. Grill,Stephan W. Grill,Alexander D. Bershadsky,Guillermo A. Gomez,Alpha S. Yap +8 more
TL;DR: It is found that the impact of mDia1 ramified beyond adherens junctions to stabilize tight junctions and maintain the epithelial permeability barrier constitutes a pathway for cadherin-based contractility to contribute to the physiology of established epithelia.
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Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin
Diptiman Choudhury,Arnab Ganguli,Debabrata Ghosh Dastidar,Bipul R. Acharya,Amlan Das,Gopal Chakrabarti +5 more
TL;DR: Interestingly, apigenin showed synergistic anti-cancer effect with another natural anti-tubulin agent curcumin, and bound at the interphase of α-β-subunit of tubulin, indicating that these ligands bind to tubulin at different sites.