Blas Morales

TL;DR: A novel measure of disease progression and a genome-wide significant signal on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2 is generated, suggesting this mechanism as an area for future therapeutic investigation.

TL;DR: In patients with PD, the presence of two long alleles, with more than 16 repeated AAT trinucleotides in the CNR1 gene, was associated with a reduced prevalence of depression, suggesting that the pharmacological manipulation of cannabinoid neurotransmission could open a new therapeutic approach for the treatment of depression in PD and possibly in other conditions.

TL;DR: Alpha‐syn was elevated early in the development of PD and specific PD treatment did not change plasma α‐syn levels, according to this study.

TL;DR: In this paper, the effect of L-dopa on lipid peroxidation (LPO) levels in patients with sporadic Parkinson's disease and in forty controls was investigated. And the results also suggest an antioxidant effect.

TL;DR: An 82‐year‐old patient, father of 3 children with autosomal recessive juvenile parkinsonism due to combined heterozygous mutations of the parkin gene, developed clinical features of SROS 2 years before death and the diagnosis was confirmed by pathology.