Brett H. Keeling

TL;DR: Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28 and highlighted a convergent pathway for monogenic, toxin and perhaps virally-induced Parkinson disease.

TL;DR: This study demonstrates a significant association between LINGO1 rs9652490 and essential tremor and Parkinson disease and provides the first evidence of a genetic link between both diseases.

TL;DR: It is suggested that pathogenic mutations in DCTN1 are rare and do not play a common role in the development of Parkinson disease, frontotemporal lobar degeneration, or amyotrophic lateral sclerosis.

TL;DR: Se sequencing of all MEIS1 and BTBD9 coding exons and exon-intron boundaries in RLS familial probands followed by assessment of segregation of novel variants with disease within families and evaluation of prevalence in patients with RLS and the general population are reported.

TL;DR: The findings do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders, and any significant association between this variant and PD or ET is not identified.