D
David Gosal
Researcher at University College Dublin
Publications - 13
Citations - 642
David Gosal is an academic researcher from University College Dublin. The author has contributed to research in topics: Medicine & Parkinsonism. The author has an hindex of 8, co-authored 8 publications receiving 610 citations. Previous affiliations of David Gosal include Mater Misericordiae Hospital.
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Journal ArticleDOI
Translation initiator EIF4G1 mutations in familial Parkinson disease
Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Justus C. Dachsel,Carles Vilariño-Güell,Sarah Lincoln,Frédéric Leprêtre,Frédéric Leprêtre,Mary M. Hulihan,Jennifer M. Kachergus,Austen J. Milnerwood,Lucia Tapia,Mee Sook Song,Emilie Le Rhun,Eugénie Mutez,Eugénie Mutez,Lydie Larvor,Lydie Larvor,A. Duflot,A. Duflot,Christel Vanbesien-Mailliot,Christel Vanbesien-Mailliot,Alexandre Kreisler,Alexandre Kreisler,Owen A. Ross,Kenya Nishioka,Alexandra I. Soto-Ortolaza,Stephanie A. Cobb,Heather L. Melrose,Bahareh Behrouz,Brett H. Keeling,Justin A. Bacon,Emna Hentati,Lindsey N. Williams,Akiko Yanagiya,Nahum Sonenberg,Paul J. Lockhart,Abba C. Zubair,Ryan J. Uitti,Jan O. Aasly,Anna Krygowska-Wajs,Grzegorz Opala,Zbigniew K. Wszolek,Roberta Frigerio,Demetrius M. Maraganore,David Gosal,Timothy Lynch,Michael Hutchinson,Anna Rita Bentivoglio,Enza Maria Valente,Enza Maria Valente,William C. Nichols,Nathan Pankratz,Tatiana Foroud,Rachel A. Gibson,Fayçal Hentati,Dennis W. Dickson,Alain Destée,Alain Destée,Matthew J. Farrer,Matthew J. Farrer +59 more
TL;DR: Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28 and highlighted a convergent pathway for monogenic, toxin and perhaps virally-induced Parkinson disease.
Journal ArticleDOI
PINK1 (PARK6) associated Parkinson disease in Ireland
Daniel G. Healy,Patrick M. Abou-Sleiman,J. M. Gibson,Owen A. Ross,S. Jain,Sonia Gandhi,David Gosal,Miratul M. K. Muqit,Nicholas W. Wood,Timothy Lynch +9 more
TL;DR: Assessment of the prevalence of PINK1 gene mutations in 290 well-characterized early- and late-onset PD patients from Ireland indicates that Pink1 mutations are a rare cause of PD in Ireland.
Journal ArticleDOI
Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
Owen A. Ross,Claire O'Neill,I. Maeve Rea,Timothy Lynch,Timothy Lynch,David Gosal,David Gosal,Andrew Wallace,Martin D. Curran,Derek Middleton,Derek Middleton,J. Mark Gibson +11 more
TL;DR: The single nucleotide polymorphism in the chemokine IL-8 gene was observed to associate with PD and appeared to be independent of age at onset, which supports the theory that the proinflammatory response in the brains of patients with PD plays a role in the pathogenesis of the disease.
Journal ArticleDOI
Familial genes in sporadic disease: Common variants of α-synuclein gene associate with Parkinson's disease
Owen A. Ross,David Gosal,David Gosal,Jeremy T. Stone,Sarah Lincoln,Michael G. Heckman,G. Brent Irvine,Janet A. Johnston,J. Mark Gibson,Matthew J. Farrer,Timothy Lynch,Timothy Lynch +11 more
TL;DR: An association of common SNCA polymorphisms with disease susceptibility in a series of Irish PD patients is identified and it is now crucial to identify the susceptibility allele and elucidate its functionality which may generate a therapeutic target for PD.
Journal ArticleDOI
Genomewide Association, Parkinson Disease, and PARK10
Matthew J. Farrer,Kristoffer Haugarvoll,Kristoffer Haugarvoll,Owen A. Ross,Jeremy T. Stone,Nicole M. Milkovic,Stephanie A. Cobb,Andrew J. Whittle,Sarah Lincoln,Mary M. Hulihan,Michael G. Heckman,Linda R. White,Jan O. Aasly,J. Mark Gibson,David Gosal,David Gosal,Timothy Lynch,Timothy Lynch,Zbigniew K. Wszolek,Ryan J. Uitti,Mathias Toft,Mathias Toft +21 more
TL;DR: The authors thank the patients and families for their participation in this study and thank Minnie Schreiber for technical assistance.