L
Laxminarasimha Donthireddy
Researcher at Wistar Institute
Publications - 16
Citations - 1284
Laxminarasimha Donthireddy is an academic researcher from Wistar Institute. The author has contributed to research in topics: Immune system & Tumor microenvironment. The author has an hindex of 8, co-authored 10 publications receiving 714 citations. Previous affiliations of Laxminarasimha Donthireddy include Adelphi University.
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Journal ArticleDOI
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
Vinit Kumar,Laxminarasimha Donthireddy,Douglas Marvel,Thomas Condamine,Fang Wang,Sergio Lavilla-Alonso,Ayumi Hashimoto,Prashanthi Vonteddu,Reeti Behera,Marlee A. Goins,Charles Mulligan,Brian Nam,Neil Hockstein,Fred Denstman,Shanti Shakamuri,David W. Speicher,Ashani T. Weeraratna,Timothy Chao,Robert H. Vonderheide,Lucia R. Languino,Peter Ordentlich,Qin Liu,Xiaowei Xu,Albert C. Lo,Ellen Puré,Chunsheng Zhang,Andrey Loboda,Manuel A. Sepulveda,Linda A. Snyder,Dmitry I. Gabrilovich +29 more
TL;DR: It is demonstrated that carcinoma-associated fibroblasts (CAF) are major sources of chemokines that recruit granulocytes to tumors, and CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
Journal ArticleDOI
Fatty acid transport protein 2 reprograms neutrophils in cancer
Filippo Veglia,Vladimir A. Tyurin,Maria Blasi,Alessandra De Leo,Andrew V. Kossenkov,Laxminarasimha Donthireddy,Tsun Ki Jerrick To,Zach Schug,Subhasree Basu,Fang Wang,Emanuela Ricciotti,Concetta C. DiRusso,Maureen E. Murphy,Robert H. Vonderheide,Paul M. Lieberman,Charles Mulligan,Brian Nam,Neil Hockstein,Gregory A. Masters,Gregory A. Masters,Michael J. Guarino,Cindy Lin,Yulia Nefedova,Paul N. Black,Valerian E. Kagan,Dmitry I. Gabrilovich +25 more
TL;DR: It is reported that mouse and human PMN-MDSCs exclusively upregulate fatty acid transport protein 2 (FATP2), and FATP2 mediates the acquisition of immunosuppressive activity by PMn-M DSCs and represents a target to inhibit the functions of PMN, MDSCs selectively and to improve the efficiency of cancer therapy.
Journal ArticleDOI
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
Filippo Veglia,Vladimir A. Tyurin,Dariush Mohammadyani,Dariush Mohammadyani,Maria Blasi,Elizabeth K. Duperret,Laxminarasimha Donthireddy,Ayumi Hashimoto,Alexandr A. Kapralov,Andrew A. Amoscato,Roberto Angelini,Sima Patel,Kevin Alicea-Torres,David B. Weiner,Maureen E. Murphy,Judith Klein-Seetharaman,Esteban Celis,Valerian E. Kagan,Dmitry I. Gabrilovich +18 more
TL;DR: It is found that impaired cross-presentation in DCs is largely associated with defect in trafficking of peptide–MHC class I (pMHC) complexes to the cell surface, caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.
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Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.
Jérôme Mastio,Thomas Condamine,George A. Dominguez,Andrew V. Kossenkov,Laxminarasimha Donthireddy,Filippo Veglia,Cindy Lin,Fang Wang,Shuyu Fu,Shuyu Fu,Jie Zhou,Patrick Viatour,Sergio Lavilla-Alonso,Alexander Polo,Evgenii N. Tcyganov,Charles Mulligan,Brian Nam,Joseph J. Bennett,Gregory A. Masters,Michael J. Guarino,Amit Kumar,Yulia Nefedova,Robert H. Vonderheide,Lucia R. Languino,Scott I. Abrams,Dmitry I. Gabrilovich +25 more
TL;DR: These precursors are barely detectable in steady state conditions and are not consequential for differentiation of granulocytes, but they accumulate in cancer and substantially contribute to PMN-MDSC expansion.
Journal ArticleDOI
Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17–producing CD4+ T cells
Myrna L. Ortiz,Vinit Kumar,Anna Martner,Sridevi Mony,Laxminarasimha Donthireddy,Thomas Condamine,John T. Seykora,Stella C. Knight,George Malietzis,Gui Han Lee,Morgan Moorghen,Brianna Lenox,Noreen Luetteke,Esteban Celis,Dmitry I. Gabrilovich +14 more
TL;DR: The accumulation of immature myeloid cells in skin tissue of patients with inflammatory conditions, which predisposes to the development of cancer, is reported.