Journal ArticleDOI
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
Tohru Ishitani,Jun Ninomiya-Tsuji,Shln Ichl Nagai,Michiru Nishita,Marc D. Meneghini,Nick Barker,Marian L. Waterman,Bruce Bowerman,Hans Clevers,Hiroshi Shibuya,Kunihiro Matsumoto +10 more
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TLDR
It is shown that TAK1 activation stimulates NLK activity and downregulates transcriptional activation mediated by β-catenin and TCF, which negatively regulates the Wnt signalling pathway.Citations
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The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Journal ArticleDOI
Wnt/beta-catenin signaling in development and disease.
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Journal ArticleDOI
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Gray W. Pearson,Fred L. Robinson,Tara Beers Gibson,Bing E. Xu,Mahesh Karandikar,Kevin S. Berman,Melanie H. Cobb +6 more
TL;DR: Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted and particular emphasis is on ERK1/2.
Journal ArticleDOI
Wnt signaling and cancer
TL;DR: In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.
Journal ArticleDOI
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
Marie Cargnello,Philippe P. Roux +1 more
TL;DR: The mechanisms of MAPKAPK activation by the different MAPKs are reviewed and their physiological roles based on established substrates and recent discoveries are discussed.
References
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Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.
Journal ArticleDOI
Functional interaction of beta-catenin with the transcription factor LEF-1.
Jürgen Behrens,von Kries Jp,Michael Kühl,Bruhn L,Bruhn L,Doris Wedlich,Rudolf Grosschedl,Rudolf Grosschedl,Walter Birchmeier +8 more
TL;DR: β-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals from cell-adhesion components or wnt protein to the nucleus.
Journal ArticleDOI
Wnt signaling: a common theme in animal development
Ken M. Cadigan,Roel Nusse +1 more
TL;DR: Current understanding of Wnt function and signaling mechanisms is reviewed in a comparative approach, highlighting novelty and underscoring questions that remain, and putting emphasis on the latest findings.
Journal ArticleDOI
β‐catenin is a target for the ubiquitin–proteasome pathway
TL;DR: It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin.
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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
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