Journal ArticleDOI
The pathophysiology of vivax malaria
Nicholas M. Anstey,Bruce Russell,Bruce Russell,Bruce Russell,Tsin W. Yeo,Ric N. Price,Ric N. Price +6 more
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TLDR
Potential mechanisms underlying the syndromes of uncomplicated and severe vivax malaria, identifying key areas for future research are discussed.About:
This article is published in Trends in Parasitology.The article was published on 2009-05-01. It has received 393 citations till now. The article focuses on the topics: Plasmodium vivax & Membrane permeability.read more
Citations
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Thousands of chemical starting points for antimalarial lead identification
Francisco-Javier Gamo,Laura M. Sanz,J. Vidal,Cristina de Cozar,Emilio Alvarez,J.L. Lavandera,Dana E. Vanderwall,Darren V. S. Green,Vinod Kumar,Samiul Hasan,James R. Brown,Catherine E. Peishoff,Lon R. Cardon,Jose F. Garcia-Bustos +13 more
TL;DR: Chemical structures and associated data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host–pathogen interaction related targets.
Journal ArticleDOI
Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite
Ivo Mueller,Mary R. Galinski,J. Kevin Baird,Jane M. Carlton,Dhanpat K. Kochar,Pedro L. Alonso,Hernando A. del Portillo,Hernando A. del Portillo +7 more
TL;DR: This Review critically examines what is known about P vivax, focusing on identifying the crucial gaps that create obstacles to the elimination of this parasite in human populations.
Journal ArticleDOI
A long neglected world malaria map: Plasmodium vivax endemicity in 2010.
Peter W. Gething,Iqbal R. F. Elyazar,Catherine L. Moyes,David L. Smith,David L. Smith,Katherine E. Battle,Carlos A Guerra,Anand P. Patil,Andrew J. Tatem,Andrew J. Tatem,Rosalind E. Howes,Monica F. Myers,Dylan B. George,Peter Horby,Heiman F. L. Wertheim,Ric N. Price,Ric N. Price,Ivo Mueller,J. Kevin Baird,Simon I. Hay,Simon I. Hay +20 more
TL;DR: This first systematic effort to map the global endemicity of Plasmodium vivax is presented, intended to contribute to a much-needed paradigm shift towards geographically stratified and evidence-based planning for P. v Vivax control and elimination.
Journal ArticleDOI
The international limits and population at risk of Plasmodium vivax transmission in 2009
Carlos A Guerra,Rosalind E. Howes,Anand P. Patil,Peter W. Gething,Thomas P. Van Boeckel,Thomas P. Van Boeckel,William H. Temperley,Caroline W Kabaria,Andrew J. Tatem,Bui H. Manh,Iqbal R. F. Elyazar,J. Kevin Baird,Robert W. Snow,Simon I. Hay +13 more
TL;DR: A contemporary evidence-based map of the global spatial extent of P. vivax malaria, together with estimates of the human population at risk (PAR) of any level of transmission in 2009, is provided to support future cartographic-based burden estimations.
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New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance.
TL;DR: Severe, fatal and multidrug-resistant vivax malaria challenge the perception of P. v Vivax as a benign disease and strategies to understand and address these phenomena are needed urgently if the global elimination of malaria is to succeed.
References
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Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J. Gardner,Neil Hall,Eula Fung,Owen White,Matthew Berriman,Richard W. Hyman,Jane M. Carlton,Arnab Pain,Karen E. Nelson,Sharen Bowman,Ian T. Paulsen,Keith D. James,Jonathan A. Eisen,Kim Rutherford,Steven L. Salzberg,Alister Craig,Sue Kyes,Man Suen Chan,Vishvanath Nene,Shamira J. Shallom,Bernard B. Suh,Jeremy Peterson,Samuel V. Angiuoli,Mihaela Pertea,Jonathan E. Allen,Jeremy D. Selengut,Daniel H. Haft,Michael W. Mather,Akhil B. Vaidya,David M. A. Martin,Alan H. Fairlamb,Martin Fraunholz,David S. Roos,Stuart A. Ralph,Geoffrey I. McFadden,Leda M. Cummings,G. Mani Subramanian,Christopher J. Mungall,J. Craig Venter,Daniel J. Carucci,Stephen L. Hoffman,Chris I. Newbold,Ronald W. Davis,Claire M. Fraser,Bart Barrell +44 more
TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Journal ArticleDOI
The pathogenic basis of malaria
TL;DR: Insight into the complexity of malaria pathogenesis is vital for understanding the disease and will provide a major step towards controlling it.
Journal ArticleDOI
Indicators of Life-Threatening Malaria in African Children
Kevin Marsh,Dayo Forster,C Waruiru,I Mwangi,Maria Winstanley,Victoria Marsh,Charles R. Newton,Peter Winstanley,Peter Warn,Norbert Peshu,Geoffrey Pasvol,Robert W. Snow +11 more
TL;DR: In African children with malaria, the presence of impaired consciousness or respiratory distress can identify those at high risk for death.
Journal ArticleDOI
Vivax Malaria: Neglected and Not Benign
Ric N. Price,Emiliana Tjitra,Carlos A Guerra,Shunmay Yeung,Nicholas J. White,Nicholas M. Anstey +5 more
TL;DR: Progress in reducing the burden of disease will require improved access to reliable diagnosis and effective treatment of both blood-stage and latent parasites, and more detailed characterization of the epidemiology, morbidity, and economic impact of vivax malaria.
Journal ArticleDOI
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Jane M. Carlton,Jane M. Carlton,John H. Adams,Joana C. Silva,Shelby L. Bidwell,Hernan Lorenzi,Elisabet Caler,Jonathan Crabtree,Jonathan Crabtree,Samuel V. Angiuoli,Emilio F. Merino,Paolo Amedeo,Qin Cheng,Richard M.R. Coulson,Brendan S. Crabb,Hernando A. del Portillo,Kobby Essien,T. Feldblyum,Carmen Fernandez-Becerra,Paul R. Gilson,Amy H. Gueye,Xiang Guo,Simon Kang’a,Taco W. A. Kooij,Michael Korsinczky,Michael Korsinczky,Esmeralda V. S. Meyer,Vish Nene,Ian T. Paulsen,Owen White,Stuart A. Ralph,Qinghu Ren,Tobias Sargeant,Steven L. Salzberg,Christian J. Stoeckert,Steven A. Sullivan,Marcio Massao Yamamoto,Stephen L. Hoffman,Jennifer R. Wortman,Malcolm J. Gardner,Mary R. Galinski,John W. Barnwell,Claire M. Fraser-Liggett +42 more
TL;DR: The synteny and isochore structure of P. vivax chromosomes are described, and it is shown that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously.