Dominique Bonnet

TL;DR: Detailed flow cytometric analysis of the marrow of highly engrafted mice demonstrated both lymphoid and myeloid differentiation, as well as the retention of a significant fraction of CD34(+) CD38(-) cells, which should be useful for identification of the cellular and molecular mechanisms that regulate primitive human hematopoietic cells.

TL;DR: The characterization of human DNGR-1+ BDCA3hi DCs and the ability to grow them in vitro opens the door for exploiting this subset in immunotherapy.

TL;DR: More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.

TL;DR: It is demonstrated that, using CD64 expression, MΦs can be distinguished from DCs in the intestine of both mice and humans and how inflammation impacts this pathway is determined, and it is shown that T cell‐mediated colitis is associated with massive recruitment of monocytes to the intestine and the mesenteric lymph node (MLN).

TL;DR: It is reported that primitive human cells capable of repopulating nonobese diabetic/severe combined immunodeficiency mice (SCID-repopulating cells; SRC) can be maintained and/or modestly increased after culture of CD34+CD38− cord blood cells in serum-free conditions, and the importance of the SRC assay is demonstrated in the development of culture conditions that support primitive cells.