B
Bryan R. Cullen
Researcher at Duke University
Publications - 376
Citations - 52946
Bryan R. Cullen is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 121, co-authored 371 publications receiving 50901 citations. Previous affiliations of Bryan R. Cullen include Hoffmann-La Roche & University of Medicine and Dentistry of New Jersey.
Papers
More filters
Journal ArticleDOI
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
TL;DR: It is demonstrated that human pre-miRNA nuclear export, and miRNA function, are dependent on Exportin-5, an additional cellular cofactor required for miRNA biogenesis and function.
Journal ArticleDOI
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
TL;DR: Together, these data show that human pri-miRNAs are not only structurally similar to mRNAs but can, in fact, function both as pri- miRNAs and m RNAs.
Journal ArticleDOI
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.
TL;DR: These results indicate that the HIV-1 rev gene product induces HIV- 1 structural gene expression by activating the sequence-specific nuclear export of incompletely spliced HIV-2 RNA species.
Journal ArticleDOI
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
Yan Zeng,Rui Yi,Bryan R. Cullen +2 more
TL;DR: It is demonstrated that an endogenously encoded human miRNA is able to cleave an mRNA bearing fully complementary target sites, whereas an exogenously supplied siRNA can inhibit the expression of an RNA bearing partially complementary sequences without inducing detectable RNA cleavage.
Journal ArticleDOI
Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells
TL;DR: It is shown that the human mir-30 miRNA can be excised from irrelevant, endogenously transcribed mRNAs encompassing the predicted 71 nucleotide mir- 30 precursor.