Carles Lerin

TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.

TL;DR: RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity.

TL;DR: The endogenous P GC-1alpha protein complex is identified and the molecular mechanism by which PGC-1 alpha acetylation by GCN5 turns off the transcriptional and biological function of this metabolic coactivator is provided.

TL;DR: The automated capabilities of eRah are demonstrated by the analysis of GC-time-of-flight (TOF) MS data from plasma samples of adolescents with hyperinsulinaemic androgen excess and healthy controls, and the quantitative results are compared to centWave, the peak-picking algorithm implemented in the widely used XCMS package, MetAlign, and ChromaTOF software.

TL;DR: The T1D patients presented a blunted metabolic response to acute exercise as compared to controls, and this attenuated response may interfere in the healthy performance or fitness of T2D patients, something that further studies should elucidate.