C
Carles Lerin
Researcher at Boston Children's Hospital
Publications - 31
Citations - 8713
Carles Lerin is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 21 publications receiving 8087 citations. Previous affiliations of Carles Lerin include Johns Hopkins University School of Medicine & University of Barcelona.
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge,Carmen Argmann,Zachary Gerhart-Hines,Hamid Meziane,Carles Lerin,Frédéric N. Daussin,Nadia Messadeq,Jill C. Milne,Philip D. Lambert,Peter J. Elliott,Bernard Geny,Markku Laakso,Pere Puigserver,Johan Auwerx +13 more
TL;DR: RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity.
Journal ArticleDOI
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α
Carles Lerin,Joseph T. Rodgers,Dario E. Kalume,Seung hee Kim,Akhilesh Pandey,Pere Puigserver +5 more
TL;DR: The endogenous P GC-1alpha protein complex is identified and the molecular mechanism by which PGC-1 alpha acetylation by GCN5 turns off the transcriptional and biological function of this metabolic coactivator is provided.
Journal ArticleDOI
eRah: A Computational Tool Integrating Spectral Deconvolution and Alignment with Quantification and Identification of Metabolites in GC/MS-Based Metabolomics
Xavier Domingo-Almenara,Jesus Brezmes,Maria Vinaixa,Sara Samino,Noelia Ramírez,Marta Ramon-Krauel,Carles Lerin,Marta Díaz,Lourdes Ibáñez,Xavier Correig,Alexandre Perera-Lluna,Oscar Yanes +11 more
TL;DR: The automated capabilities of eRah are demonstrated by the analysis of GC-time-of-flight (TOF) MS data from plasma samples of adolescents with hyperinsulinaemic androgen excess and healthy controls, and the quantitative results are compared to centWave, the peak-picking algorithm implemented in the widely used XCMS package, MetAlign, and ChromaTOF software.
Journal ArticleDOI
Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus.
Laura Brugnara,Maria Vinaixa,Serafín Murillo,Sara Samino,Miguel Á. Rodríguez,Antoni Beltran,Carles Lerin,Gareth W. Davison,Xavier Correig,Anna Novials +9 more
TL;DR: The T1D patients presented a blunted metabolic response to acute exercise as compared to controls, and this attenuated response may interfere in the healthy performance or fitness of T2D patients, something that further studies should elucidate.