C
Carlos R. Escalante
Researcher at Virginia Commonwealth University
Publications - 47
Citations - 3020
Carlos R. Escalante is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Helicase & DNA. The author has an hindex of 20, co-authored 46 publications receiving 2731 citations. Previous affiliations of Carlos R. Escalante include King's College London & Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors.
Shuwen Liu,Gengfu Xiao,Yibang Chen,Yuxian He,Jinkui Niu,Carlos R. Escalante,Huabao Xiong,James Farmar,Asim K. Debnath,Po Tien,Shibo Jiang +10 more
TL;DR: CP-1 might be modifiable to increase its anti-SARS-CoV activity and could be further developed as an antiviral agent for treatment or prophylaxis of SARS- coV infection.
Journal ArticleDOI
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
TL;DR: The crystal structure of the IRF-1 region bound to the natural positive regulatory domain I (PRD I) DNA element from the interferon-β promoter provides the first three-dimensional view of a member of the growing IRF family, revealing a new helix–turn–helix motif that latches onto DNA through three of the five conserved tryptophans.
Journal ArticleDOI
Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η: Implications for Translesion DNA Synthesis
José Trincão,Robert E. Johnson,Carlos R. Escalante,Satya Prakash,Louise Prakash,Aneel K. Aggarwal +5 more
TL;DR: The crystal structure of the catalytic core of S. cerevisiae DNA polymerase eta, determined at 2.25A resolution, reveals a polydactyl right hand-shaped molecule with a unique polymerase-associated domain this article.
Journal ArticleDOI
A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1–IRF Complexes
Elke Glasmacher,Smita Agrawal,Abraham B Chang,Theresa L. Murphy,Wenwen Zeng,Bryan Vander Lugt,Aly A. Khan,Maria Ciofani,Chauncey J. Spooner,Sascha Rutz,Jason A. Hackney,Roza Nurieva,Carlos R. Escalante,Wenjun Ouyang,Dan R. Littman,Kenneth M. Murphy,Harinder Singh +16 more
TL;DR: Chromatin immunoprecipitation sequencing in T helper 17 (TH17) cells reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)–IRF composite elements (AICEs) that are co-bound by BATF, an AP-1 factor required for TH17, B, and dendritic cell differentiation.
Journal ArticleDOI
Transcription Corepressor CtBP Is an NAD+-Regulated Dehydrogenase
Vivek Kumar,Justin E. Carlson,Kenneth A. Ohgi,Thomas A. Edwards,David W. Rose,Carlos R. Escalante,Michael G. Rosenfeld,Aneel K. Aggarwal +7 more
TL;DR: Chinnadurai et al. as mentioned in this paper showed that minal binding protein (CtBP) is a functional dehy-dehyde-acid dehydrogenase (D2HED) related protein.