C
Carol Churcher
Researcher at Wellcome Trust Sanger Institute
Publications - 84
Citations - 42290
Carol Churcher is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 57, co-authored 78 publications receiving 38695 citations. Previous affiliations of Carol Churcher include Wellcome Trust & University of Cambridge.
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Journal ArticleDOI
Sequence of Plasmodium falciparum chromosomes 1, 3–9 and 13
Neil Hall,Arnab Pain,Matthew Berriman,Carol Churcher,Barbara Harris,David Harris,Karen Mungall,S. Bowman,S. Bowman,Rebecca Atkin,Stephen Baker,Andy Barron,Karen Brooks,Caroline O. Buckee,Christine Burrows,Inna Cherevach,C. Chillingworth,Tracey Chillingworth,Zoe Christodoulou,Louise Clark,Richard Clark,Craig Corton,Ann Cronin,Robert L. Davies,P. Davis,Paul H. Dear,F. Dearden,Jonathon Doggett,Theresa Feltwell,Arlette Goble,Ian Goodhead,R. Gwilliam,N. Hamlin,Zahra Hance,D. Harper,Heidi Hauser,T. Hornsby,S. Holroyd,Paul Horrocks,Sean Humphray,Kay Jagels,Keith D. James,D. Johnson,Arnaud Kerhornou,Andrew J Knights,Bernard Anri Konfortov,S Kyes,Natasha Larke,Daniel Lawson,Nicola Lennard,Alexandra Line,Mark Maddison,J. McLean,P. Mooney,Sharon Moule,Lee Murphy,Karen Oliver,Douglas Ormond,Claire Price,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Simon Rutter,Kim Rutherford,Mandy Sanders,Mark Simmonds,Kathy Seeger,Sarah Sharp,Robert B. Smith,R. Squares,S. Squares,K. Stevens,K. Taylor,Adrian Tivey,Louise Unwin,S. Whitehead,John Woodward,John Sulston,Alister Craig,Alister Craig,Chris I. Newbold,Bart Barrell +81 more
TL;DR: The sequence of chromosomes 1, 3–9 and 13 of P. falciparum clone 3D7 is reported—these chromosomes account for approximately 55% of the total genome, and a highly conserved sequence element is identified in the intergenic region of internal var genes that is not associated with their telomeric counterparts.
Journal ArticleDOI
Telomeric expression sites are highly conserved in Trypanosoma brucei.
Christiane Hertz-Fowler,Luisa M. Figueiredo,Michael A. Quail,Marion Becker,Andrew C Jackson,Nathalie Bason,Karen Brooks,Carol Churcher,Samah Fahkro,Ian Goodhead,Paul Trafford Heath,Magdalena Kartvelishvili,Karen Mungall,David K. Harris,Heidi Hauser,Mandy Sanders,David L. Saunders,Kathy Seeger,Sarah Sharp,Jesse E. Taylor,Danielle Walker,Brian White,Rosanna E. B. Young,George A. M. Cross,Gloria Rudenko,J. David Barry,Edward J. Louis,Matthew Berriman +27 more
TL;DR: Phylogenetic analysis of constituent ESAG families suggests that BESs are sequence mosaics and that extensive recombination has shaped the evolution of the BES repertoire, a widely used strategy for immune evasion in pathogens, and telomere biology.
Journal ArticleDOI
Complete Genome Sequence and Lytic Phase Transcription Profile of a Coccolithovirus
William H. Wilson,Declan C. Schroeder,Michael J. Allen,Matthew T. G. Holden,Julian Parkhill,Bart Barrell,Carol Churcher,N. Hamlin,Karen Mungall,Halina Norbertczak,Michael A. Quail,Claire Price,Ester Rabbinowitsch,Danielle Walker,Marie Craigon,Douglas Roy,Peter Ghazal +16 more
TL;DR: The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi and contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery.
Journal ArticleDOI
Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes
Mohammed Sebaihia,Michael W. Peck,Nigel P. Minton,Nicholas R. Thomson,Matthew T. G. Holden,Wilfrid J. Mitchell,Andrew T. Carter,Stephen D. Bentley,David R. Mason,Lisa Crossman,Catherine J. Paul,Alasdair Ivens,Marjon H.J. Wells-Bennik,Ian J. Davis,Ana Cerdeño-Tárraga,Carol Churcher,Michael A. Quail,Tracey Chillingworth,Theresa Feltwell,Audrey Fraser,Ian Goodhead,Zahra Hance,Kay Jagels,Natasha Larke,Mark Maddison,Sharon Moule,Karen Mungall,Halina Norbertczak,Ester Rabbinowitsch,Mandy Sanders,Mark Simmonds,Brian White,Sally Whithead,Julian Parkhill +33 more
TL;DR: The genome indicates that C. botulinum is adapted to a saprophytic lifestyle both in soil and aquatic environments, and reveals a hitherto unknown ability of C.Botulinum to degrade chitin.
Journal ArticleDOI
Complete Genome Sequence of Uropathogenic Proteus mirabilis, a Master of both Adherence and Motility
Melanie M. Pearson,Mohammed Sebaihia,Carol Churcher,Michael A. Quail,Aswin Sai Narain Seshasayee,Nicholas M. Luscombe,Zahra Abdellah,Claire Arrosmith,Becky Atkin,Tracey Chillingworth,Heidi Hauser,Kay Jagels,Sharon Moule,Karen Mungall,Halina Norbertczak,Ester Rabbinowitsch,Danielle Walker,Sally Whithead,Nicholas R. Thomson,Philip N. Rather,Julian Parkhill,Harry L. T. Mobley +21 more
TL;DR: The complete genome sequence of P. mirabilis HI4320 is reported, a representative strain cultured in the laboratory from the urine of a nursing home patient with a long-term (> or =30 days) indwelling urinary catheter.