Caroline E. Lilley

TL;DR: A multiscale approach to assemble a host-pathogen biochemical network containing 213 confirmed host cellular factors and 11 HIV-1-encoded proteins has uncovered multiprotein virus-host interactions that likely act in concert to facilitate the early steps of HIV- 1 infection.

TL;DR: It is demonstrated that the Mre11 complex can function as a damage sensor upstream of ATM/ATR signaling in mammalian cells.

TL;DR: It is shown that hA3A is catalytically active and that it, but none of the other APOBEC3 family members, potently inhibits replication of the parvovirus adeno-associated virus (AAV).

TL;DR: It is shown that AAVP provides superior tumor transduction over phage and that incorporation of inverted terminal repeats is associated with improved fate of the delivered transgene and the temporal dynamics and spatial heterogeneity of gene expression mediated by targeted AAVP can be monitored by positron emission tomography.

TL;DR: It is reported that herpes simplex virus 1 (HSV-1) infection can activate and exploit a cellular DNA damage response that aids viral replication in nonneuronal cells, and the failure of neurons to mount aDNA damage response to HSV- 1 may contribute to the establishment of latency.