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Carsten Behrens
Researcher at Novo Nordisk
Publications - 58
Citations - 4495
Carsten Behrens is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Glucagon receptor & Glucagon. The author has an hindex of 21, co-authored 58 publications receiving 4305 citations. Previous affiliations of Carsten Behrens include University of Copenhagen & Millipore Corporation.
Papers
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Journal ArticleDOI
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Michael Egholm,Ole Buchardt,Leif Christensen,Carsten Behrens,Susan M. Freier,David A. Driver,Rolf H. Berg,Seog K. Kim,Bengt Nordén,Peter E. Nielsen +9 more
TL;DR: It is reported here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the WatsonCrick base-pairing rules, and thus is a true DNA mimic in terms of base- Pair recognition.
Journal ArticleDOI
Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization
Kim L. Dueholm,Michael Egholm,Carsten Behrens,Leif Christensen,Henrik Hansen,Tore Vulpius,Kenneth H. Petersen,Rolf H. Berg,Peter E. Nielsen,Ole Buchardt +9 more
TL;DR: The preparation of mixed-sequence PNAs (PNAs containing the four natural nucleobases; thymine, cytosine, adenine, and guanine) is described, essentially following standard solid phase peptide synthesis protocols.
Patent
Glucagon antagonists/inverse agonists
TL;DR: In this paper, a novel class of compounds, which act to antagonize the action of the glucagon hormone on the receptor, were proposed for the treatment and prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.
Journal ArticleDOI
Small-molecule agonists for the glucagon-like peptide 1 receptor
Lotte Bjerre Knudsen,Dan Kiel,Min Teng,Carsten Behrens,Dilip Bhumralkar,János Tibor Kodra,Jens J. Holst,Claus Bekker Jeppesen,Michael D. L. Johnson,Johannes Cornelis De Jong,Anker Steen Jorgensen,Tim Kercher,Jarek Kostrowicki,Peter Madsen,Preben H. Olesen,Jacob S. Petersen,Fritz Poulsen,Ulla G. Sidelmann,Jeppe Sturis,Larry Kenneth Truesdale,John F. May,Jesper Lau +21 more
TL;DR: A series of small molecules known as ago-allosteric modulators selective for the human GLP-1 receptor are discovered, which act as both allosteric activators of the receptor and independent agonists.
Journal ArticleDOI
Engineered CHO cells for production of diverse, homogeneous glycoproteins.
Zhang Yang,Shengjun Wang,Adnan Halim,Morten Alder Schulz,Morten Frödin,Shamim Herbert Rahman,Malene Bech Vester-Christensen,Malene Bech Vester-Christensen,Carsten Behrens,Claus Kristensen,Sergey Y. Vakhrushev,Eric P. Bennett,Hans H. Wandall,Henrik Clausen +13 more
TL;DR: An engineering approach will aid the production of glycoproteins with improved properties and therapeutic potential by constructing a design matrix that facilitates the generation of desired glycosylation, such as human-like α2,6-linked sialic acid capping.