Z
Zhang Yang
Researcher at University of Copenhagen
Publications - 50
Citations - 2948
Zhang Yang is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Glycosylation & Glycan. The author has an hindex of 20, co-authored 43 publications receiving 1783 citations. Previous affiliations of Zhang Yang include National Research Foundation of South Africa & Aarhus University.
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Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Charlotte B Spliid,Charlotte B Spliid,Jessica Pihl,Jessica Pihl,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,Elizabeth M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sumit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +42 more
TL;DR: A model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2 is suggested, in which Manipulation of hepara sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,E. M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Gordts, Plsm, Chanda, S. K.,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +34 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain and may represent new therapeutic opportunities for exogenous heparin.
Journal ArticleDOI
Engineered CHO cells for production of diverse, homogeneous glycoproteins.
Zhang Yang,Shengjun Wang,Adnan Halim,Morten Alder Schulz,Morten Frödin,Shamim Herbert Rahman,Malene Bech Vester-Christensen,Malene Bech Vester-Christensen,Carsten Behrens,Claus Kristensen,Sergey Y. Vakhrushev,Eric P. Bennett,Hans H. Wandall,Henrik Clausen +13 more
TL;DR: An engineering approach will aid the production of glycoproteins with improved properties and therapeutic potential by constructing a design matrix that facilitates the generation of desired glycosylation, such as human-like α2,6-linked sialic acid capping.
Journal ArticleDOI
Fast and sensitive detection of indels induced by precise gene targeting
Zhang Yang,Catharina Steentoft,Camilla Hauge,Lars Hansen,Allan Lind Thomsen,Francesco Niola,Malene Bech Vester-Christensen,Morten Frödin,Henrik Clausen,Hans H. Wandall,Eric P. Bennett +10 more
TL;DR: A method for fast, sensitive and simple indel detection that accurately defines indel sizes down to ±1 bp is presented, based on tri-primer amplicon labelling and DNA capillary electrophoresis detection and is amenable for high throughput analysis.
Journal ArticleDOI
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
Yoshiki Narimatsu,Hiren J. Joshi,Rebecca Nason,Julie Van Coillie,Richard Karlsson,Lingbo Sun,Zilu Ye,Yen-Hsi Chen,Katrine T. Schjoldager,Catharina Steentoft,Sanae Furukawa,Barbara A. Bensing,Paul M. Sullam,Andrew J. Thompson,James C. Paulson,Christian Büll,Christian Büll,Gosse J. Adema,Ulla Mandel,Lars Hansen,Eric P. Bennett,Ajit Varki,Sergey Y. Vakhrushev,Zhang Yang,Henrik Clausen +24 more
TL;DR: Broad utility of the cell-based glycan array is demonstrated, and the higher order binding of microbial adhesins to clustered patches of O-glycans organized by their presentation on proteins is uncovered.