Carsten Behrens

TL;DR: It is reported here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the Watson–Crick base-pairing rules, and thus is a true DNA mimic in terms of base- Pair recognition.

TL;DR: The preparation of mixed-sequence PNAs (PNAs containing the four natural nucleobases; thymine, cytosine, adenine, and guanine) is described, essentially following standard solid phase peptide synthesis protocols.

TL;DR: In this paper, a novel class of compounds, which act to antagonize the action of the glucagon hormone on the receptor, were proposed for the treatment and prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.

TL;DR: A series of small molecules known as ago-allosteric modulators selective for the human GLP-1 receptor are discovered, which act as both allosteric activators of the receptor and independent agonists.

TL;DR: An engineering approach will aid the production of glycoproteins with improved properties and therapeutic potential by constructing a design matrix that facilitates the generation of desired glycosylation, such as human-like α2,6-linked sialic acid capping.