C
Catherine A. Meldrum
Researcher at University of Michigan
Publications - 40
Citations - 1318
Catherine A. Meldrum is an academic researcher from University of Michigan. The author has contributed to research in topics: COPD & Spirometry. The author has an hindex of 17, co-authored 33 publications receiving 1037 citations.
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Journal ArticleDOI
Noninvasive Imaging Biomarker Identifies Small Airway Damage in Severe Chronic Obstructive Pulmonary Disease.
Dragoş M. Vasilescu,Fernando J. Martinez,Nathaniel Marchetti,Craig J. Galbán,Charles R. Hatt,Catherine A. Meldrum,Chandra Dass,Naoya Tanabe,Rishindra M. Reddy,Amir Lagstein,Brian D. Ross,Wassim W. Labaki,Susan Murray,Xia Meng,Jeffrey L. Curtis,Tillie L. Hackett,Ella A. Kazerooni,Gerard J. Criner,James C. Hogg,MeiLan K. Han +19 more
TL;DR: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD) and computed tomography densitometry has been demonstrated to identify these lesions.
Journal ArticleDOI
Lung CD8+ T cells in COPD have increased expression of bacterial TLRs
Christine M. Freeman,Christine M. Freeman,Fernando J. Martinez,MeiLan K. Han,George R. Washko,Alexandra L. McCubbrey,Stephen W. Chensue,Douglas A. Arenberg,Catherine A. Meldrum,Lisa McCloskey,Jeffrey L. Curtis +10 more
TL;DR: It is suggested that as lung function worsens in COPD, the auto-aggressive behavior of lung CD8+ T cells could increase in response to microbial TLR ligands, specifically ligands against TLR2/1.
Journal ArticleDOI
Meeting the challenge of COPD care delivery in the USA: a multiprovider perspective
MeiLan K. Han,Carlos H. Martinez,David H. Au,David H. Au,Jean Bourbeau,Cynthia M. Boyd,Richard D. Branson,Gerard J. Criner,Ravi Kalhan,Thomas J Kallstrom,Angela King,Jerry A. Krishnan,Suzanne C. Lareau,Todd A. Lee,Kathleen O. Lindell,David M. Mannino,Fernando J. Martinez,Catherine A. Meldrum,Valerie G. Press,Byron Thomashow,Laura Tycon,Jamie L. Sullivan,John MacLaren Walsh,Kevin C. Wilson,Kevin C. Wilson,Jean Wright,Barbara P. Yawn,Patrick M. Zueger,Surya P. Bhatt,Mark T. Dransfield,Mark T. Dransfield +30 more
TL;DR: This Commission summarises expert opinion from key stakeholders-patients, caregivers, and medical professionals, as well as representatives from health systems, insurance companies, and industry-to understand barriers to care delivery and propose potential solutions.
Journal ArticleDOI
Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS
Carlos H. Martinez,Alejandro A. Diaz,Catherine A. Meldrum,Jeffrey L. Curtis,Christopher B. Cooper,Cheryl S. Pirozzi,Richard E. Kanner,Robert Paine,Robert Paine,Prescott G. Woodruff,Eugene R. Bleecker,Nadia N. Hansel,R. Graham Barr,Nathaniel Marchetti,Gerard J. Criner,Ella A. Kazerooni,Eric A. Hoffman,Brian D. Ross,Craig J. Galbán,Christine T. Cigolle,Fernando J. Martinez,MeiLan K. Han +21 more
TL;DR: In never‐ and ever‐smokers without airflow obstruction, aging is associated with increased FVC and CT‐defined functional small airway abnormality regardless of respiratory symptoms.
Journal ArticleDOI
Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease.
Christine M. Freeman,Valerie R. Stolberg,Sean Crudgington,Fernando J. Martinez,MeiLan K. Han,Stephen W. Chensue,Douglas A. Arenberg,Catherine A. Meldrum,Lisa McCloskey,Jeffrey L. Curtis +9 more
TL;DR: As spirometry worsens in COPD, CD56+ lung lymphocytes exhibit spontaneous cytotoxicity of autologous structural lung cells, supporting their potential role in emphysema progression.