Carlos H. Martinez

TL;DR: This longitudinal, prospective analysis of exacerbations in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort identified several novel biomarkers associated with consistent exacerbations, including CT-defined small airway abnormality on CT, lower interleukin-15 concentrations, and higher interleucin-8 concentrations.

TL;DR: In never‐ and ever‐smokers without airflow obstruction, aging is associated with increased FVC and CT‐defined functional small airway abnormality regardless of respiratory symptoms.

TL;DR: Quantifying comorbidity provides a more thorough understanding of the risk for patient-centered outcomes in COPD and performs well to quantify comorbridity in a diverse population with COPD.

TL;DR: Subgroups of smokers defined by upper‐lobe or lower-lobe emphysema predominance exhibit different functional and radiological disease progression rates, and the upper‐ lobe predominant subtype shows evidence of association with known COPD genetic risk variants.

TL;DR: Age-related differences in HRQL may be explained by a higher impact of dyspnea among younger subjects with COPD, confirming that for the same severity of Dyspnea there is a stronger association with HRQL among younger individuals.