C
Charles Antzelevitch
Researcher at Lankenau Institute for Medical Research
Publications - 527
Citations - 58069
Charles Antzelevitch is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: Brugada syndrome & Repolarization. The author has an hindex of 118, co-authored 515 publications receiving 54661 citations. Previous affiliations of Charles Antzelevitch include University of Southern California & Main Line Health.
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Contemporary Definitions and Classification of the Cardiomyopathies An American Heart Association Scientific Statement From the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention
Barry J. Maron,Jeffrey A. Towbin,Gaetano Thiene,Charles Antzelevitch,Domenico Corrado,Donna K. Arnett,Arthur J. Moss,Christine E. Seidman,James B. Young +8 more
TL;DR: The present classification scheme recognizes the rapid evolution of molecular genetics in cardiology, as well as the introduction of several recently described diseases, and is unique in that it incorporates ion channelopathies as a primary cardiomyopathy.
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Brugada Syndrome: Report of the Second Consensus Conference Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
Charles Antzelevitch,Pedro Brugada,Martin Borggrefe,Josep Brugada,Ramon Brugada,Domenico Corrado,Ihor Gussak,Herve LeMarec,Koonlawee Nademanee,Andrés Ricardo Pérez Riera,Wataru Shimizu,Eric Schulze-Bahr,H.L. (Hanno) Tan,Arthur A.M. Wilde +13 more
TL;DR: The present report elaborates further on the diagnostic criteria and examines risk stratification schemes and device and pharmacological approaches to therapy on the basis of the available clinical and basic science data.
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Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Qiuyun Chen,Glenn E. Kirsch,Danmei Zhang,Ramon Brugada,Josep Brugada,Pedro Brugada,Domenico Potenza,Angel Moya,Martin Borggrefe,Günter Breithardt,Rocio Ortiz-Lopez,Zhiqing Wang,Charles Antzelevitch,Richard E. O'Brien,Eric Schulze-Bahr,Mark T. Keating,Jeffrey A. Towbin,Qing Wang +17 more
TL;DR: It is shown that sodium channels with the missense mutation recover from inactivation more rapidly than normal and that the frameshift mutation causes the sodium channel to be non-functional.
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Cellular Basis for the Brugada Syndrome and Other Mechanisms of Arrhythmogenesis Associated With ST-Segment Elevation
Gan-Xin Yan,Charles Antzelevitch +1 more
TL;DR: Depression or loss of the action potential dome in RV epicardium creates a transmural voltage gradient that may be responsible for the ST-segment elevation observed in the Brugada syndrome and other syndromes exhibiting similar ECG manifestations.
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Cellular Basis for the Normal T Wave and the Electrocardiographic Manifestations of the Long-QT Syndrome
Gan-Xin Yan,Charles Antzelevitch +1 more
TL;DR: The authors' data suggest that the "pathophysiological U" wave observed in acquired or congenital LQTS is more likely to be a second component of an interrupted T wave, and argue for use of the term T2 in place of U to describe this event.