Rebecca Berry

TL;DR: Evidence for genetic locus heterogeneity was observed and genetic mapping of the locus represents an important initial step in the identification of an X-linked gene implicated in the aetiology of HPC.

TL;DR: In this paper, the authors conducted a genomewide search on 162 North American families with ≥ 3 members affected with prostate cancer (PRCA) and found evidence for linkage to chromosome 20q13 with two-point parametric LOD scores >1 at multiple sites, with the highest two-points LOD score of 2.69 for marker D20S196.

TL;DR: Mutation analysis revealed genetic alterations in LKB1 in two probands who had a family history of PJS, suggesting the presence of significant genetic heterogeneity for PJS and the involvement of other loci in this syndrome.

TL;DR: The argument that prostate cancer is a heterogeneous disease and that multiple genetic and environmental factors may be important for its etiology is strengthened.

TL;DR: BRCA1 and BRCA2 appear to have a limited role in familial prostate cancer, and families with both prostate and breast cancer may result from mutations in other predisposition genes.