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Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
Papers
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Journal ArticleDOI
Vimentin DNA methylation predicts survival in breast cancer.
Jacob C. Ulirsch,Cheng Fan,George J. Knafl,Ming Jing Wu,Brett Coleman,Charles M. Perou,Theresa Swift-Scanlan +6 more
TL;DR: Vimentin methylation predicted poor overall survival independent of race, subtype, stage, nodal status, or metastatic disease and holds promise as a new prognostic biomarker for breast cancer patients.
Book ChapterDOI
Multiple Instance Learning for Heterogeneous Images: Training a CNN for Histopathology
Heather D. Couture,James Stephen Marron,Charles M. Perou,Melissa A. Troester,Marc Niethammer +4 more
TL;DR: In this paper, a quantile function was proposed to provide a more complete description of the heterogeneity within each image, improving image-level classification by aggregating predictions from smaller regions of the image into an imagelevel classification.
Journal ArticleDOI
Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
Adam C. Pond,Jason I. Herschkowitz,Kathryn L. Schwertfeger,Bryan E. Welm,Yiqun Zhang,Brian York,Robert D. Cardiff,Susan G. Hilsenbeck,Charles M. Perou,Chad J. Creighton,Richard E. Lloyd,Jeffrey M. Rosen +11 more
TL;DR: The results suggest that cooperation of the FGF and Wnt pathways in mammary tumorigenesis is based on the activation of protein translational pathways that result in increased expression of Wnt/beta-catenin target genes (at the level of protein translation).
Journal ArticleDOI
Race-associated biological differences among Luminal A breast tumors
Monica D'Arcy,Jodie M. Fleming,Whitney R. Robinson,Erin L. Kirk,Charles M. Perou,Charles M. Perou,Melissa A. Troester,Melissa A. Troester +7 more
TL;DR: In this article, gene expression data from 108 CAU and 57 AA breast tumors were analyzed to identify potential biological differences by race among Luminal A breast cancers, and the expression of race-associated genes were evaluated for associations with survival.
Journal ArticleDOI
Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.
Jacquelyn J. Bower,Leah D. Vance,Matthew A. Psioda,Stephanie L. Smith-Roe,Stephanie L. Smith-Roe,Dennis A. Simpson,Joseph G. Ibrahim,Katherine A. Hoadley,Charles M. Perou,William K. Kaufmann +9 more
TL;DR: The findings imply that pharmacological targeting of signaling pathways driving these phenotypes may lead to the development of novel personalized treatment strategies for the latter two subtypes which currently lack targeted therapeutic options because of their triple negative breast cancer status.