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Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
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Journal ArticleDOI
Clinical implementation of the intrinsic subtypes of breast cancer.
TL;DR: All three gene sets were signifi cant predictors of outcomes in univariate and multivariate testing, which suggests that this is a robust classifi cation method, and there is little value to draw conclusions about the robustness and utility of a test based on research data from independent laboratories not intended for concordance testing.
Journal ArticleDOI
Erratum: Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles (Cell Reports (2017) 18(11) (2780–2794) (S2211124717302140) (10.1016/j.celrep.2017.02.033))
Vincenzo Cardinale,Eugenio Gaudio,Domenico Alvaro,Antonio Franchitto,Jean-Pierre A. Kocher,Timothy Defreitas,Robert S. Fulton,Robert Penny,André Lopes Carvalho,John N. Weinstein,Roeland Verhaak,Jay Bowen,M.M. Matsushita,Piotr A. Mieczkowski,Stacey Gabriel,Rachna T. Shroff,Mario Berrios,David E. Kleiner,David Mallery,Yunhu Wan,Zixing Wang,Qiang Sun,Joshua M. Stuart,Eric Chuah,Michael Mayo,Martin L. Ferguson,Gordon Saksena,Suhn K. Rhie,Andrew J. Mungall,Saianand Balu,Juok Cho,Andrew D. Cherniack,H. Stoppler,Ronglai Shen,Kimberley Evason,Pei Lin,Richard A. Moore,Chia Chin Wu,Lawrence N. Kwong,Angela Tam,Andrea Holbrook,Erik Zmuda,Mitesh J. Borad,Loretta K. Allotey,Catrina Fronick,Julie M. Gastier-Foster,A.G. Robertson,Rehan Akbani,Catherine D. Moser,Steven E. Schumacher,Jia Liu,Juliann Shih,Peter W. Laird,Josh Stuart,Margi Sheth,Marie-Claude Gingras,Elaine R. Mardis,J.T. Auman,Jacqueline E. Schein,Jeffrey Roach,Yussanne Ma,K. Mungall,Giannicola Genovese,Maria Consiglia Bragazzi,Joel S. Parker,Johanna Gardner,W.K. Rathmell,Denise Brooks,Lisle E. Mose,Tara Skelly,Shaowu Meng,Elizabeth L. Appelbaum,Mi Ni Huang,Youyong Lu,Gad Getz,Arshi Arora,Mark Gerken,Gian Luca Grazi,Jesper B. Andersen,Erin Curley,Corbin D. Jones,Siyuan Zheng,Steven J.M. Jones,Douglas Voet,W.C. Foo,Ed Reznik,D. Alvaro,Lixing Yang,Rashi Naresh,Roongruedee Chaiteerakij,Rameen Beroukhim,Ju Dong Yang,Heidi J. Sofia,Jean C. Zenklusen,Scott Morris,Tom Bodenheimer,Noreen Dhalla,Wenbin Liu,V. Cardinale,Reanne Bowlby,Nilsa C. Ramirez,Oliver F. Bathe,Adrian Ally,Joseph Paulauskis,Charles M. Perou,Apurva M. Hegde,Heather K. Schmidt,Roy Tarnuzzer,Nicolas Stransky,Stuart R. Jefferys,A.X. Zhu,Apurva M. Hegde,Michael Torbenson,Julian M. Hess,Miruna Balasundaram,Farshad Farshidfar,Amie Radenbaugh,Richard A. Gibbs,Rebecca Carlsen,Toshinori Hinoue,Ina Felau,Katayoon Kasaian,Nasra H. Giama,Daniel Crain,Nils Gehlenborg,A.J. McRee,Matthew G. Soloway,Sudha Chudamani,Li Ding,T. Mounajjed,Lewis R. Roberts,Nina Thiessen,Phillip H. Lai,Ewan A. Gibb,Felice Giuliante,Daniel R. O'Brien,Robert A. Holt,Christopher A. Miller,Lori Boice,Lynda Chin,Guido Carpino,Rose A.M. De,D Wheeler,Eve Shinbrot,Laxmi Lolla,John A. Demchok,Todd Pihl,Matthew Meyerson,Eugenio Gaudio,Leigh B. Thorne,Robin Kate Kelley,Janae V. Simons,A. Franchitto,Amy H. Perou,Donghui Tan,V. Deshpande,Yan Shi,Yulia Newton,Akinyemi I. Ojesina,GB Mills,L.A. Fulton,Juinhua Zhang,Kyle R. Covington,Alan P. Hoyle,Chandra Pedamallu,Marco A. Marra,Scott Frazer,Michael S. Noble,Kristen M. Leraas,Matthew G. Cordes,Rick K. Wilson,Yang Wu,Bradley A. Murray,Cindy Sander,Carrie Cibulskis,Carolyn M. Hutter,Jong Kyoung Kim,Candace Shelton,Michael S. Lawrence,D.N. Hayes,Tina Wong,Daniel J. Weisenberger,Hongzheng Zhang,Den Berg D.J. Van,Lisa Wise,Sara Sadeghi,Tara M. Lichtenberg,Liu Xi,Gina Choe,Tushar Patel,V.C. Chandan,David I. Heiman,Payal Sipahimalani,Moiz S. Bootwalla,Troy Shelton,Katherine A. Hoadley,Umadevi Veluvolu,Nabeel Bardeesy,Jason Roszik,Sam Meier,Stephen B. Baylin,Michael D. McLellan +201 more
Proceedings ArticleDOI
Meta-analysis Results from the Collaborative Trials in Neoadjuvant Breast Cancer (CTNeoBC)
Patricia Cortazar,Lijun Zhang,Michael Untch,Keyur Mehta,Joseph P. Costantino,Norman Wolmark,Hervé Bonnefoi,David Cameron,Luca Gianni,Pinuccia Valagussa,Jo Anne Zujewski,Robert Justice,Sibylle Loibl,Lawrence Wickerham,Jan Bogaerts,José Baselga,Charles M. Perou,Gideon M. Blumenthal,Jens Uwe Blohmer,Eleftherios P. Mamounas,Jonas Bergh,Vladimir Semiglazov,Tatiana M. Prowell,Holger Eidtmann,Soonmyung Paik,Martine Piccart,Rajeshwari Sridhara,Peter A. Fasching,Sandra M. Swain,Leen Slaets,Shenghui Tang,Bernd Gerber,Charles E. Geyer,Richard Pazdur,Nina Ditsch,Priya Rastogi,Wolfgang Eiermann,Gunter von Mincwitz +37 more
Journal ArticleDOI
Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch
James M. Haughian,Mauricio P. Pinto,J. Chuck Harrell,Brian S Bliesner,Kristiina Joensuu,Wendy W. Dye,Carol A. Sartorius,Aik Choon Tan,Päivi Heikkilä,Charles M. Perou,Kathryn B. Horwitz +10 more
TL;DR: A previously unrecognized plasticity of ER+PR+ luminal breast cancers is established that mobilizes outgrowth of hormone-resistant basal-like disease in response to treatment and can be prevented by combining endocrine therapies with Notch inhibition.
Journal ArticleDOI
MYC is amplified in BRCA1-associated breast cancers.
Tatyana A. Grushko,James J. Dignam,Soma Das,Anne Blackwood,Charles M. Perou,Karin K. Ridderstråle,Kristin N. Anderson,Min Jie Wei,April J. Adams,Fitsum Hagos,Lise Sveen,Henry T. Lynch,Barbara L. Weber,Olufunmilayo I. Olopade +13 more
TL;DR: The data indicate that MYC oncogene amplification contributes to tumor progression in BRCA1-associated breast cancers, and conclude that the aggressive histopathological features of BRCa1- associated tumors are in part due to dysregulated MYC activity.