C
Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
Papers
More filters
Journal ArticleDOI
Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue respository of the Surveillance, Epidemiology, and End Results (SEER) program
William F. Anderson,Sheng Luo,Nilanjan Chatterjee,Philip S. Rosenberg,Rayna K. Matsuno,Marc T. Goodman,Brenda Y. Hernandez,Marsha E. Reichman,M. P. Dolled-Filhart,Ruth O'Regan,M Garcia-Closas,Charles M. Perou,Ismail Jatoi,Richard W. Cartun,Mark E. Sherman +14 more
TL;DR: Though sample sizes were small, this demonstration project validates the potential utility of the RTR for supplementing the SEER program and showed contrasting incidence patterns for HER2+ (her2+ER−) and ER+ (HER2−ER+) breast cancers, diagnosed in 1995.
Patent
Methods and compositions involving intrinsic genes
TL;DR: In this article, compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer are discussed and discussed. But none of the methods are related to cancer detection and classification.
Journal ArticleDOI
Primary breast tumor-derived cellular models: characterization of tumorigenic, metastatic, and cancer-associated fibroblasts in dissociated tumor (DT) cultures
Katherine Drews-Elger,Joeli Brinkman,Philip Miller,Sanket Shah,J. Chuck Harrell,Thiago G. da Silva,Zheng Ao,Amy Schlater,Diana J. Azzam,Kathleen M. Diehl,Dafydd G. Thomas,Joyce M. Slingerland,Charles M. Perou,Marc E. Lippman,Dorraya El-Ashry +14 more
TL;DR: Six cellular models derived from the dissociation of primary breast tumor specimens are reported, referred to as “dissociated tumor (DT) cells,” which provide closer-to-primary cellular models for the study of breast cancer pathogenesis, metastasis, and TME.
Journal ArticleDOI
Differentiation and loss of malignant character of spontaneous pulmonary metastases in patient-derived breast cancer models.
Jessica Bockhorn,Jessica Bockhorn,Aleix Prat,Ya Fang Chang,Xia Liu,Simo Huang,Meng Shang,Chika Nwachukwu,Maria J. Gomez-Vega,J. Chuck Harrell,Olufunmilayo I. Olopade,Charles M. Perou,Huiping Liu +12 more
TL;DR: Interestingly, relative to the parental primary breast tumors, the lung metastasis (met)-derived mammary tumors exhibited a slower growth rate and a reduced metastatic potential with a more differentiated epithelial status.
Journal ArticleDOI
Separation of breast cancer and organ microenvironment transcriptomes in metastases
Mohammad A. Alzubi,Tia H. Turner,Amy L. Olex,Sahib S. Sohal,Nicholas P. Tobin,Susana Garcia Recio,Jonas Bergh,Thomas Hatschek,Joel S. Parker,Carol A. Sartorius,Charles M. Perou,Mikhail G. Dozmorov,J. Chuck Harrell +12 more
TL;DR: It is hypothesized that pathways upregulated in metastases are mediators of viability and that simultaneously targeting changes within different cancer cell pathways and/or different tissue compartments may be needed for inhibition of disease progression.