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Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
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The Use of Bayesian Hierarchical Models for Adaptive Randomization in Biomarker-Driven Phase II Studies
TL;DR: This work advocates Bayesian hierarchical models for response-adaptive randomized phase II studies integrating single or multiple biomarkers, which is an efficient design for evaluating treatment efficacy within biomarker subgroups, with less variable final sample sizes when compared to nested staged designs.
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MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data
TL;DR: MultiK as discussed by the authors identifies reproducible groups in scRNA-seq data, thus providing an objective means to estimate the number of possible groups or cell-type populations present, and achieves high robustness through a consensus clustering approach.
Journal Article
Hormone receptor negative and basal-like subtypes are overrepresented in invasive breast carcinoma from women of African ancestry
Offiong Francis Ikpatt,Jinhua Xu,Andrey Kramtsov,R. Ndoma-Egba,Charles M. Perou,Olufunmilayo I. Olopade +5 more
TL;DR: The results suggest that molecularly portraits of breast tumors are broadly conserved between women of African and European ancestry, with a majority of tumors from Nigeria lacking the expression of important therapeutic targets like ER, HER2 and HER1.
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TBCRC 030: A randomized phase II study of preoperative cisplatin versus paclitaxel in TNBC—Evaluating the homologous recombination deficiency (HRD) biomarker.
Erica L. Mayer,Vandana G. Abramson,Rachel C. Jankowitz,Carla I. Falkson,Paul K. Marcom,Tiffany A. Traina,Lisa A. Carey,Mothaffar F. Rimawi,Jennifer M. Specht,Kathy D. Miller,Vered Stearns,Charles M. Perou,Andrea L. Richardson,Nadine Tung,William T. Barry,Zhenying Tan-Wasielewski,Kirsten Timms,Anne-Renee Hartman,Antonio C. Wolff,Eric P. Winer +19 more
TL;DR: The HRD assay detects impaired dsDNA break repair and may identify BRCA1/2-proficie...
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A retroviral vector for siRNA expression in mammalian cells
Gro Leite Størvold,Elisabet Gjernes,Elisabet Gjernes,Elisabet Gjernes,Hanne A. Askautrud,A.L. Børresen-Dale,Charles M. Perou,Eirik Frengen,Eirik Frengen,Eirik Frengen +9 more
TL;DR: A retroviral-based shRNA expression vector, pSiRPG, is constructed and modified to harbor an enhanced green fluorescent protein (EGFP) and a puromycin selection marker and should facilitate functional studies in breast cell lines that are hard to transfect with conventional plasmid-based methods.