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Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
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Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
Vessela N. Kristensen,Charles J. Vaske,Josie Ursini-Siegel,Peter Van Loo,Peter Van Loo,Silje H. Nordgard,Ravi Sachidanandam,Therese Sørlie,Fredrik Wärnberg,Vilde D. Haakensen,Åslaug Helland,Bjørn Naume,Charles M. Perou,David Haussler,Olga G. Troyanskaya,Anne Lise Børresen-Dale +15 more
TL;DR: It is demonstrated that by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, this work can stratify immune signatures that predict patient survival.
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Finding large average submatrices in high dimensional data
TL;DR: In this article, a statistically motivated biclustering procedure (LAS) is proposed to find large average submatrices within a given real-valued data matrix, and the procedure operates in an iterative-residual fashion, and is driven by a Bonferroni-based significance score that effectively trades off between submatrix size and average value.
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Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.
Pu Wang,Pu Wang,Jing Wu,Shenghong Ma,Lei Zhang,Jun Yao,Katherine A. Hoadley,Matthew D. Wilkerson,Charles M. Perou,Kun-Liang Guan,Kun-Liang Guan,Dan Ye,Yue Xiong,Yue Xiong +13 more
TL;DR: It is reported here that D-2-HG inhibits the α-KG-dependent alkB homolog (ALKBH) DNA repair enzymes, suggesting that impairment of DNA repair may contribute to tumorigenesis driven by IDH mutations and that alkylating agents may merit exploration for treating IDH-mutated cancer patients.
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Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures
Cheng Fan,Aleix Prat,Joel S. Parker,Yufeng Liu,Lisa A. Carey,Melissa A. Troester,Charles M. Perou +6 more
TL;DR: Integration of gene expression signatures and clinical-pathological factors is an improved method over either variable type alone and can be used to build predictors of therapy responsiveness, and could ultimately be applied to other tumor types.
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ABRA: improved coding indel detection via assembly-based realignment
TL;DR: ABRA, an assembly-based realigner, which uses an efficient and flexible localized de novo assembly followed by global realignment to more accurately remap reads results in enhanced performance for indel detection as well as improved accuracy in variant allele frequency estimation.