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Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
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Journal ArticleDOI
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Aleix Prat,Olga Karginova,Joel S. Parker,Cheng Fan,Xiaping He,Lisa M. Bixby,J. Chuck Harrell,Erick Roman,Barbara Adamo,Melissa A. Troester,Charles M. Perou +10 more
TL;DR: The results presented here help to improve the understanding of the wide range of breast cancer cell line models through the appropriate pairing of cell lines with relevant in vivo tumor and normal cell counterparts.
Journal ArticleDOI
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.
Adam D. Pfefferle,Jason I. Herschkowitz,Jerry Usary,J. C. Harrell,Benjamin T. Spike,Jessica R. Adams,Maria I. Torres-Arzayus,Myles Brown,Sean E. Egan,Geoffrey M. Wahl,Jeffrey M. Rosen,Charles M. Perou +11 more
TL;DR: This study of murine models of breast carcinoma encompasses the largest comprehensive genomic dataset to date to identify human-to-mouse disease subtype counterparts and indicates that multiple genetically engineered mouse models are needed to represent the diversity of human breast cancers.
Journal ArticleDOI
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
Alexandra Thomas,Eric D. Routh,Ashok K. Pullikuth,Guangxu Jin,Jing Su,Jeff W. Chou,Katherine A. Hoadley,Cristin G. Print,Nicholas Knowlton,Michael A. Black,Sandra Demaria,Ena Wang,Davide Bedognetti,Wendell D. Jones,Gaurav Mehta,Michael L. Gatza,Charles M. Perou,David B. Page,Pierre L. Triozzi,Lance D. Miller +19 more
TL;DR: A previously unappreciated role for TMB as a determinant of immune-mediated survival of breast cancer patients is demonstrated and candidate immune-regulatory mechanisms associated with immunologically cold tumors are identified.
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A compact VEGF signature associated with distant metastases and poor outcomes
Zhiyuan Hu,Cheng Fan,Chad A. Livasy,Xiaping He,Daniel S. Oh,Matthew G. Ewend,Lisa A. Carey,Subbaya Subramanian,Robert B. West,Francis Ikpatt,Olufunmilayo I. Olopade,Matt van de Rijn,Charles M. Perou +12 more
TL;DR: This signature suggests that the response to hypoxia includes the ability to promote new blood and lymphatic vessel formation, and that the dual targeting of multiple cell types and pathways will be needed to prevent metastatic spread.
Journal ArticleDOI
Cell-Type-Specific Responses to Chemotherapeutics in Breast Cancer
Melissa A. Troester,Katherine A. Hoadley,Therese Sørlie,Brittney-Shea Herbert,Anne Lise Børresen-Dale,Per Eystein Lønning,Jerry W. Shay,William K. Kaufmann,Charles M. Perou +8 more
TL;DR: In vivo data corroborated the cell-type-specific responses to chemotherapeutics observed in vitro, including the induction of p21waf1, and similarities between in vivo and in vitro responses help to identify important response mechanisms to chemtherapeutics.