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Charles M. Perou
Researcher at University of North Carolina at Chapel Hill
Publications - 645
Citations - 235604
Charles M. Perou is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 156, co-authored 573 publications receiving 202951 citations. Previous affiliations of Charles M. Perou include North Carolina Central University & University of Chicago.
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Journal ArticleDOI
Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
Clémence Thomas,Whitney S. Henry,Benjamin G. Cuiffo,Anthony Y. Collmann,Elisabetta Marangoni,Vanessa Benhamo,Manoj Bhasin,Cheng Fan,Laetitia Fuhrmann,Albert S. Baldwin,Charles M. Perou,Anne Vincent-Salomon,Alex Toker,Antoine E. Karnoub,Antoine E. Karnoub,Antoine E. Karnoub +15 more
TL;DR: Transcriptomic analysis of activated PIK3CA–expressing BLBC cells identified the gene encoding the humoral pattern recognition molecule pentraxin-3 (PTX3) as a critical target of oncogenic PI3K signaling and shows that PTX3 expression is greater in tumor samples from patients with BLBC and that it is prognostic of poor patient survival.
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FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease
Susana García-Recio,Aatish Thennavan,Michael P. East,Joel S. Parker,Juan Miguel Cejalvo,Joseph P. Garay,Daniel P. Hollern,Xiaping He,Kevin R. Mott,Patricia Galván,Cheng Fan,Sara R. Selitsky,Alisha R. Coffey,David Marron,Fara Brasó-Maristany,Octavio Burgues,Joan Albanell,Federico Rojo,Ana Lluch,Eduardo Martínez de Dueñas,Jeffery M. Rosen,Gary L. Johnson,Lisa A. Carey,Aleix Prat,Charles M. Perou +24 more
TL;DR: A link between FGFR4-regulated genes and metastasis is identified, suggesting treatment options for FGFR2-positive patients, whose high expression is not caused by mutation or amplification, and in the METABRIC breast cancer cohort.
Journal ArticleDOI
Breast cancer molecular profiles and tumor response of neoadjuvant doxorubicin and paclitaxel: The I-SPY TRIAL (CALGB 150007/150012, ACRIN 6657)
LJ Esserman,Charles M. Perou,Maggie C.U. Cheang,AM DeMichele,Lisa A. Carey,L.J. van 't Veer,Joe W. Gray,E. Petricoin,Kathleen Conway,Nola M. Hylton,Donald A. Berry,I-Spy Trial Investigators +11 more
TL;DR: The primary aim of this study was to evaluate the role of EMT in the development of central giant cell granuloma in meningitis and found that EMT may have an important role in the prognosis.
Journal ArticleDOI
Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer.
Sneha Sundaram,Alex J. Freemerman,Amy R. Johnson,J. Justin Milner,Kirk K. McNaughton,Joseph A. Galanko,Katharine M. Bendt,David B. Darr,Charles M. Perou,Melissa A. Troester,Liza Makowski +10 more
TL;DR: It is demonstrated that HGF/c-Met plays an important role in obesity-associated carcinogenesis, and neutralization of secreted HGF blunted tumor cell migration, further linking obesity-mediated HGF-dependent effects to in vitro measures of tumor aggressiveness.
Journal ArticleDOI
Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Yeji An,Jessica R. Adams,Daniel P. Hollern,Anthony Zhao,Stephen Chang,Miki S. Gams,Philip E.D. Chung,Philip E.D. Chung,Xiaping He,Rhea Jangra,Juhi S. Shah,Joanna Yang,Lauren A. Beck,Nandini Raghuram,Katelyn. J. Kozma,Amanda J. Loch,Wei Wang,Cheng Fan,Susan J. Done,Susan J. Done,Eldad Zacksenhaus,Eldad Zacksenhaus,Cynthia J. Guidos,Charles M. Perou,Sean E. Egan +24 more
TL;DR: It is reported that deletion of Cdh1, together with activation of Pik3ca in mammary epithelium of genetically modified mice, leads to formation of IR-ILC-like tumors with immune cell infiltration, as well as gene expression linked to T-regulatory (Treg) cell signaling and activation of targetable immune checkpoint pathways.