C
Chieko Kitada
Researcher at Takeda Pharmaceutical Company
Publications - 133
Citations - 12316
Chieko Kitada is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Peptide sequence. The author has an hindex of 48, co-authored 133 publications receiving 11776 citations.
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Journal ArticleDOI
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Kazuhiko Tatemoto,Masaki Hosoya,Yugo Habata,Ryo Fujii,Tadao Kakegawa,Min-Xu Zou,Yuji Kawamata,Shoji Fukusumi,Shuji Hinuma,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Masahiko Fujino +12 more
TL;DR: Synthetic peptides derived from the C-terminal amino acid sequence of bovine preproapelin were capable of specifically promoting the acidification rate in the cells expressing the APJ receptor in a range from 10(-7) to 10(-10) M, indicating that apelin is an endogenous ligand for theAPJ receptor.
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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
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Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38).
Atsuro Miyata,Lun Jiang,Raymond D. Dahl,Chieko Kitada,Kazuki Kubo,Masahiko Fujino,Naoto Minamino,Akira Arimura +7 more
TL;DR: Synthetic PACAP27 which shows a considerable homology with vasoactive intestinal polypeptide (VIP) demonstrated a similar vasodepressor activity as VIP, but the adenylate cyclase stimulating activity was about 1000 times greater than VIP.
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Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes.
TL;DR: The highest concentration of radioimmunoassayable PACAP38 was found in the hypothalamus, but other brain regions also contained considerable amounts ofPACAP38, and the total amount of PACAP in both testes exceeded its content in the whole brain.
Journal ArticleDOI
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Shuji Hinuma,Yasushi Shintani,Shoji Fukusumi,Norio Iijima,Yoshio Matsumoto,Masaki Hosoya,Ryo Fujii,Takuya Watanabe,Kuniko Kikuchi,Yasuko Terao,Takahiko Yano,Takanori Yamamoto,Yuji Kawamata,Yugo Habata,Mari Asada,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masaki Tanaka,Yasuhiko Ibata,Masahiko Fujino +21 more
TL;DR: In this paper, the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3, has been reported.