E
Elli Kyratzi
Researcher at Academy of Athens
Publications - 12
Citations - 825
Elli Kyratzi is an academic researcher from Academy of Athens. The author has contributed to research in topics: LRRK2 & Allele frequency. The author has an hindex of 10, co-authored 12 publications receiving 699 citations. Previous affiliations of Elli Kyratzi include Foundation for Biomedical Research & National and Kapodistrian University of Athens.
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Journal ArticleDOI
Stress, the stress system and the role of glucocorticoids.
Nicolas C. Nicolaides,Elli Kyratzi,Agaristi Lamprokostopoulou,George P. Chrousos,Evangelia Charmandari +4 more
TL;DR: The central and peripheral components of thestress system are described, a comprehensive overview of the stress response is provided, and the role of glucocorticoids in a broad spectrum of stress-related diseases is discussed.
Journal ArticleDOI
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Owen A. Ross,Alexandra I. Soto-Ortolaza,Michael G. Heckman,Jan O. Aasly,Nadine Abahuni,Grazia Annesi,Justin A. Bacon,Soraya Bardien,Maria Bozi,Alexis Brice,Laura Brighina,Christine Van Broeckhoven,Christine Van Broeckhoven,Jonathan Carr,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Efthimios Dardiotis,Dennis W. Dickson,Nancy N. Diehl,Alexis Elbaz,Alexis Elbaz,Carlo Ferrarese,Alessandro Ferraris,Brian K. Fiske,J. Mark Gibson,Rachel A. Gibson,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,John P. A. Ioannidis,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Chin-Hsien Lin,Timothy Lynch,Demetrius M. Maraganore,George D. Mellick,Eugénie Mutez,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Sung Sup Park,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Jessie Theuns,Jessie Theuns,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Simone Van De Loo,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Matthew J. Farrer,Matthew J. Farrer +70 more
TL;DR: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk, and are important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed.
Journal ArticleDOI
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells.
TL;DR: It is found that S18Y, but not WT, UCH-L1 confers a specific antioxidant protective function when expressed at physiological levels in human neuroblastoma cells and primary cortical neurons, and this function may underlie the protective effects of this variant in certain PD populations.
Journal ArticleDOI
Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.
Michael G. Heckman,Alexandra I. Soto-Ortolaza,Jan O. Aasly,Nadine Abahuni,Grazia Annesi,Justin A. Bacon,Soraya Bardien,Maria Bozi,Alexis Brice,Laura Brighina,Jonathan Carr,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Dennis W. Dickson,Nancy N. Diehl,Alexis Elbaz,Carlo Ferrarese,Brian K. Fiske,J. Mark Gibson,Rachel A. Gibson,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,Magdalena Boczarska-Jedynak,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Suzanne Lesage,Suzanne Lesage,Chin-Hsien Lin,Timothy Lynch,Demetrius M. Maraganore,George D. Mellick,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Sung Sup Park,Simona Petrucci,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Jessie Theuns,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Christine Van Broeckhoven,Simone Van De Loo,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Fayçal Hentati,Matthew J. Farrer,Owen A. Ross +62 more
TL;DR: Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.
Journal ArticleDOI
The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
Michael G. Heckman,Alexis Elbaz,Alexandra I. Soto-Ortolaza,Daniel J. Serie,Jan O. Aasly,Grazia Annesi,Georg Auburger,Justin A. Bacon,Magdalena Boczarska-Jedynak,Maria Bozi,Laura Brighina,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Efthimios Dardiotis,Alain Destée,Alain Destée,Carlo Ferrarese,Alessandro Ferraris,Brian K. Fiske,Suzana Gispert,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,John P. A. Ioannidis,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Chin-Hsien Lin,Katja Lohmann,Marie-Anne Loriot,Marie-Anne Loriot,Marie-Anne Loriot,Timothy Lynch,George D. Mellick,Eugénie Mutez,Eugénie Mutez,Grzegorz Opala,Sung Sup Park,Simona Petrucci,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Enza Maria Valente,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Georgia Xiromerisiou,Georgia Xiromerisiou,Demetrius M. Maraganore,Matthew J. Farrer,Owen A. Ross +64 more
TL;DR: The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes as mentioned in this paper.