J
J. Mark Gibson
Researcher at Mater Misericordiae University Hospital
Publications - 22
Citations - 1605
J. Mark Gibson is an academic researcher from Mater Misericordiae University Hospital. The author has contributed to research in topics: Population & LRRK2. The author has an hindex of 15, co-authored 22 publications receiving 1514 citations.
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Journal ArticleDOI
Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations
Jennifer M. Kachergus,Ignacio F. Mata,Mary M. Hulihan,Julie P. Taylor,Sarah Lincoln,Jan O. Aasly,J. Mark Gibson,Owen A. Ross,Timothy Lynch,Timothy Lynch,Joseph Wiley,Joseph Wiley,Haydeh Payami,John G. Nutt,Demetrius M. Maraganore,Krzysztof Czyzewski,Maria Styczyńska,Zbigniew K. Wszolek,Matthew J. Farrer,Mathias Toft +19 more
TL;DR: It is demonstrated that LRRK2 G2019S accounts for parkinsonism in several families within Europe and North America, highlighting the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis.
Journal ArticleDOI
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Owen A. Ross,Alexandra I. Soto-Ortolaza,Michael G. Heckman,Jan O. Aasly,Nadine Abahuni,Grazia Annesi,Justin A. Bacon,Soraya Bardien,Maria Bozi,Alexis Brice,Laura Brighina,Christine Van Broeckhoven,Christine Van Broeckhoven,Jonathan Carr,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Efthimios Dardiotis,Dennis W. Dickson,Nancy N. Diehl,Alexis Elbaz,Alexis Elbaz,Carlo Ferrarese,Alessandro Ferraris,Brian K. Fiske,J. Mark Gibson,Rachel A. Gibson,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,John P. A. Ioannidis,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Chin-Hsien Lin,Timothy Lynch,Demetrius M. Maraganore,George D. Mellick,Eugénie Mutez,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Sung Sup Park,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Jessie Theuns,Jessie Theuns,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Simone Van De Loo,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Matthew J. Farrer,Matthew J. Farrer +70 more
TL;DR: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk, and are important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed.
Journal ArticleDOI
mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish
Owen A. Ross,Rose McCormack,Lynn D. Maxwell,R Alistair Duguid,Derek J. Quinn,Yvonne Barnett,I. Maeve Rea,Omar M. A. El-Agnaf,J. Mark Gibson,Andrew Wallace,Derek Middleton,Derek Middleton,Martin D. Curran +12 more
TL;DR: Findings lead one to postulate that the mt4216C variant, in linkage with the mtDNA TJ cluster, may influence mitochondrial dysfunction, resulting in an increased risk of PD.
Journal ArticleDOI
Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.
Alexis Elbaz,Owen A. Ross,John P. A. Ioannidis,John P. A. Ioannidis,Alexandra I. Soto-Ortolaza,Frédéric Moisan,Jan O. Aasly,Grazia Annesi,Maria Bozi,Laura Brighina,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Alain Destée,Alain Destée,Carlo Ferrarese,Alessandro Ferraris,J. Mark Gibson,Suzana Gispert,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Barbara Jasinska-Myga,Christine Klein,Rejko Krüger,Jean-Charles Lambert,Katja Lohmann,Simone Van De Loo,Marie-Anne Loriot,Marie-Anne Loriot,Marie-Anne Loriot,Timothy Lynch,George D. Mellick,George D. Mellick,George D. Mellick,Eugénie Mutez,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Leonidas Stefanis,Ryan J. Uitti,Enza Maria Valente,Carles Vilariño-Güell,Carles Vilariño-Güell,Karin Wirdefeldt,Zbigniew K. Wszolek,Georgia Xiromerisiou,Georgia Xiromerisiou,Demetrius M. Maraganore,Matthew J. Farrer,Matthew J. Farrer +52 more
TL;DR: The independent and joint effects of the genes encoding alpha‐synuclein and microtubule‐associated protein tau in Parkinson disease (PD) are studied as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.
Journal ArticleDOI
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Rejko Krüger,Manu Sharma,Olaf Riess,Thomas Gasser,Christine Van Broeckhoven,Jessie Theuns,Jan O. Aasly,Grazia Annesi,Anna Rita Bentivoglio,Alexis Brice,Ana Djarmati,Alexis Elbaz,Matthew J. Farrer,Carlo Ferrarese,J. Mark Gibson,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,Barbara Jasinska-Myga,Christine Klein,Jean-Charles Lambert,Suzanne Lesage,Juei-Jueng Lin,Timothy Lynch,George D. Mellick,George D. Mellick,Francesa de Nigris,Grzegorz Opala,Alessandro Prigione,Aldo Quattrone,Owen A. Ross,Wataru Satake,Peter A. Silburn,Peter A. Silburn,Eng-King Tan,Tatsushi Toda,Hiroyuki Tomiyama,Hiroyuki Tomiyama,Karin Wirdefeldt,Zbigniew K. Wszolek,Georgia Xiromerisiou,Georgia Xiromerisiou,Demetrius M. Maraganore +43 more
TL;DR: This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide.