Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Charlotte L. Scott,Fang Zheng,Fang Zheng,Patrick De Baetselier,Liesbet Martens,Yvan Saeys,Sofie De Prijck,Saskia Lippens,Chloé Abels,Steve Schoonooghe,Geert Raes,Nick Devoogdt,Bart N. Lambrecht,Alain Beschin,Martin Guilliams +14 more
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TLDR
It is shown that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells, like embryonic precursors if the niche is available to them.Abstract:
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them.read more
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A lineage of myeloid cells independent of Myb and hematopoietic stem cells
Elisa Gomez Perdiguero,Christian Schulz,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Jacobsen Sew.,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: Schulz et al. as discussed by the authors investigated whether adult macrophages all share a common developmental origin and found that a population of yolk-sac-derived, tissue-resident macophages was able to develop and persist in adult mice in the absence of hematopoietic stem cells.
Journal ArticleDOI
Tissue-Resident Macrophage Ontogeny and Homeostasis.
TL;DR: The exact nature of the embryonic progenitors that give rise to adult tissue-resident macrophages is still debated, and the mechanisms enabling macrophage population maintenance in the adult are undefined.
Journal ArticleDOI
Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
Anat Shemer,Jonathan Grozovski,Tuan Leng Tay,Jenhan Tao,Alon Volaski,Patrick Süß,Alberto Ardura-Fabregat,Mor Gross-Vered,Jung-Seok Kim,Eyal David,Louise Chappell-Maor,Lars Thielecke,Christopher K. Glass,Kerstin Cornils,Marco Prinz,Steffen Jung +15 more
TL;DR: It is established that graft-derived macrophages acquire, over time, microglia characteristics, including ramified morphology, longevity, radio-resistance and clonal expansion, however, even after prolonged CNS residence, transcriptomes and chromatin accessibility landscapes of engrafted, BM-derived Macrophages remain distinct from yolk sac-derived host microglial.
Journal ArticleDOI
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations.
Sonya A. MacParland,Sonya A. MacParland,Jeff C. Liu,Xue Zhong Ma,Brendan T. Innes,Agata Bartczak,Blair K. Gage,Justin Manuel,Nicholas Khuu,Juan Echeverri,Ivan Linares,Rahul Gupta,Michael L Cheng,Lewis Y. Liu,Damra Camat,Sai W. Chung,Rebecca K. Seliga,Zigong Shao,Elizabeth Lee,Shinichiro Ogawa,Mina Ogawa,Michael D. Wilson,Jason E. Fish,Jason E. Fish,Markus Selzner,Anand Ghanekar,David R. Grant,Paul D. Greig,Gonzalo Sapisochin,Nazia Selzner,Neil Winegarden,Oyedele Adeyi,Oyedele Adeyi,Oyedele Adeyi,Gordon Keller,Gordon Keller,Gordon Keller,Gary D. Bader,Ian D. McGilvray +38 more
TL;DR: A map of the cellular landscape of the human liver using single-cell RNA sequencing is reported, and distinct populations of intrahepatic macrophages that may play specific roles in liver disease are identified.
Journal ArticleDOI
Liver macrophages in tissue homeostasis and disease
Oliver Krenkel,Frank Tacke +1 more
TL;DR: Novel findings regarding the origin, classification and function of hepatic macrophages are highlighted, and their divergent roles in the healthy and diseased liver are discussed.
References
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Journal ArticleDOI
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Simon Yona,Ki-Wook Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,Alexander V. Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,Steffen Jung +14 more
TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Journal ArticleDOI
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Christian Schulz,Elisa Gomez Perdiguero,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Sten Eirik W. Jacobsen,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: It is found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS)macrophages and for the development of YS-derived F4/80bright macrophage populations in several tissues.
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis (vol 38, pg 79, 2013)
Simon Yona,K-W Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,A Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,S Jung +14 more
TL;DR: In this paper, a fate-mapping study of the macrophage compartment is presented, taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression.
Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
Journal Article
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
Elisa Gomez Perdiguero,Christian Schulz,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Jacobsen Sew.,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: Schulz et al. as discussed by the authors investigated whether adult macrophages all share a common developmental origin and found that a population of yolk-sac-derived, tissue-resident macophages was able to develop and persist in adult mice in the absence of hematopoietic stem cells.