T
Tata Nageswara Rao
Researcher at University Hospital of Basel
Publications - 38
Citations - 4262
Tata Nageswara Rao is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 20, co-authored 33 publications receiving 3339 citations. Previous affiliations of Tata Nageswara Rao include Joslin Diabetes Center & Howard Hughes Medical Institute.
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Journal ArticleDOI
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomas Thomou,Marcelo A. Mori,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Masahiro Konishi,Masaji Sakaguchi,Christian Wolfrum,Tata Nageswara Rao,Tata Nageswara Rao,Jonathon N. Winnay,Ruben Garcia-Martin,Steven K. Grinspoon,Phillip Gorden,C. Ronald Kahn +13 more
TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
Journal ArticleDOI
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
Monika S. Kowalczyk,Itay Tirosh,Dirk Heckl,Tata Nageswara Rao,Tata Nageswara Rao,Atray Dixit,Brian J. Haas,Rebekka K. Schneider,Amy J. Wagers,Benjamin L. Ebert,Aviv Regev,Aviv Regev +11 more
TL;DR: It is found that cell cycle dominates the variability within each population and that there is a lower frequency of cells in the G1 phase among old compared with young long-term HSCs, suggesting that they traverse through G1 faster.
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Rejuvenation of regeneration in the aging central nervous system
Julia M. Ruckh,Jing-Wei Zhao,Jennifer L. Shadrach,Peter van Wijngaarden,Tata Nageswara Rao,Amy J. Wagers,Robin J.M. Franklin +6 more
TL;DR: It is shown that remyelination of experimentally induced demyelinating activity is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis, and that remYelination-enhancing therapies targeting endogenous cells can be effective throughout life.
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Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies.
TL;DR: The data show that the C57BL/6‐inbred reporter mice are ideally suited for sophisticated lineage‐tracing experiments requiring sensitive and quantitative detection/purification of live Cre‐expressing cells and their progeny.
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Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice
Nariaki Asada,Masayuki Takase,Jin Nakamura,Akiko Oguchi,Misako Asada,Norio Suzuki,Ken Ichi Yamamura,Narihito Nagoshi,Shinsuke Shibata,Tata Nageswara Rao,Hans Joerg Fehling,Atsushi Fukatsu,Naoko Minegishi,Naoko Minegishi,Toru Kita,Takeshi Kimura,Hideyuki Okano,Masayuki Yamamoto,Motoko Yanagita +18 more
TL;DR: It is demonstrated that the majority of erythropoietin-producing fibroblasts in the healthy kidney originate from myelin protein zero-Cre (P0-Cre) lineage-labeled extrarenal cells, which enter the embryonic kidney at E13.5.