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Brent S. Pedersen
Researcher at University of Utah
Publications - 110
Citations - 9792
Brent S. Pedersen is an academic researcher from University of Utah. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 39, co-authored 102 publications receiving 7115 citations. Previous affiliations of Brent S. Pedersen include University of Colorado Boulder & National Institutes of Health.
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Journal ArticleDOI
Nanopore sequencing and assembly of a human genome with ultra-long reads
Miten Jain,Sergey Koren,Karen H. Miga,Josh Quick,Arthur C Rand,Thomas A Sasani,John R. Tyson,Andrew D Beggs,Alexander T. Dilthey,Ian T. Fiddes,Sunir Malla,Hannah Marriott,Tom Nieto,Justin O'Grady,Hugh E. Olsen,Brent S. Pedersen,Arang Rhie,Hollian Richardson,Aaron R. Quinlan,Terrance P. Snutch,Louise Tee,Benedict Paten,Adam M. Phillippy,Jared T. Simpson,Jared T. Simpson,Nicholas J. Loman,Matthew Loose +26 more
TL;DR: Ultra-long reads enabled assembly and phasing of the 4-Mb major histocompatibility complex (MHC) locus in its entirety, measurement of telomere repeat length, and closure of gaps in the reference human genome assembly GRCh38.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
Tasha E. Fingerlin,Elissa Murphy,Weiming Zhang,Anna L. Peljto,Kevin K. Brown,Mark P. Steele,James E. Loyd,Gregory P. Cosgrove,David A. Lynch,Steve D. Groshong,Harold R. Collard,Paul J. Wolters,Williamson Z. Bradford,Karl Kossen,Scott D. Seiwert,Roland M. du Bois,Christine Kim Garcia,Megan S. Devine,Gunnar Gudmundsson,Helgi J Isaksson,Naftali Kaminski,Yingze Zhang,Kevin F. Gibson,Lisa Lancaster,Joy D. Cogan,Wendi R. Mason,Toby M. Maher,Philip L. Molyneaux,Athol U. Wells,Miriam F. Moffatt,Moisés Selman,Annie Pardo,Dong Soon Kim,James D. Crapo,Barry J. Make,Elizabeth A. Regan,Dinesha Walek,Jerry Daniel,Yoichiro Kamatani,Diana Zelenika,Keith P Smith,David McKean,Brent S. Pedersen,Janet Talbert,Ravin N. Kidd,Cheryl Markin,Kenneth B. Beckman,Mark Lathrop,Mark Lathrop,Marvin I. Schwarz,David A. Schwartz +50 more
TL;DR: The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Journal ArticleDOI
GOATOOLS: A Python library for Gene Ontology analyses.
D. V. Klopfenstein,Liangsheng Zhang,Brent S. Pedersen,Fidel Ramírez,Alex Warwick Vesztrocy,Aurélien Naldi,Christopher J. Mungall,Jeffrey M. Yunes,Olga Botvinnik,Mark Weigel,Will Dampier,Christophe Dessimoz,Patrick Flick,Haibao Tang +13 more
TL;DR: GOATOOLS, a Python-based library, makes it more efficient to stay current with the latest ontologies and annotations, perform gene ontology enrichment analyses to determine over- and under-represented terms, and organize results for greater clarity and easier interpretation using a novel GOATOOLs GO grouping method.
Journal ArticleDOI
Mosdepth: quick coverage calculation for genomes and exomes
TL;DR: Mosdepth is a new command‐line tool for rapidly calculating genome‐wide sequencing coverage that uses a simple algorithm that is computationally efficient and enables it to quickly produce coverage summaries.
Journal ArticleDOI
Following tetraploidy in an Arabidopsis ancestor, genes were removed preferentially from one homeolog leaving clusters enriched in dose-sensitive genes
TL;DR: It is found that islands of retention contain "connected genes," those genes predicted-by the gene balance hypothesis-to be resistant to removal because the products they encode interact with other products in a dose-sensitive manner, creating a web of dependency.