M
Mark P. Steele
Researcher at University of Colorado Denver
Publications - 81
Citations - 6312
Mark P. Steele is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Idiopathic interstitial pneumonia. The author has an hindex of 35, co-authored 75 publications receiving 5294 citations. Previous affiliations of Mark P. Steele include Vanderbilt University & Truman Medical Center.
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Journal ArticleDOI
A common MUC5B promoter polymorphism and pulmonary fibrosis
Max A. Seibold,Anastasia L. Wise,Marcy C. Speer,Mark P. Steele,Kevin K. Brown,James E. Loyd,Tasha E. Fingerlin,Weiming Zhang,Gunnar Gudmundsson,Steve D. Groshong,Christopher M. Evans,Stavros Garantziotis,Kenneth B. Adler,Burton F. Dickey,Roland M. du Bois,Ivana V. Yang,Aretha Herron,Dolly Kervitsky,Janet Talbert,Cheryl Markin,Joungjoa Park,Anne L. Crews,Susan Slifer,Scott S. Auerbach,Michelle G. Roy,Jia Lin,Corinne E. Hennessy,Marvin I. Schwarz,David A. Schwartz +28 more
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
Tasha E. Fingerlin,Elissa Murphy,Weiming Zhang,Anna L. Peljto,Kevin K. Brown,Mark P. Steele,James E. Loyd,Gregory P. Cosgrove,David A. Lynch,Steve D. Groshong,Harold R. Collard,Paul J. Wolters,Williamson Z. Bradford,Karl Kossen,Scott D. Seiwert,Roland M. du Bois,Christine Kim Garcia,Megan S. Devine,Gunnar Gudmundsson,Helgi J Isaksson,Naftali Kaminski,Yingze Zhang,Kevin F. Gibson,Lisa Lancaster,Joy D. Cogan,Wendi R. Mason,Toby M. Maher,Philip L. Molyneaux,Athol U. Wells,Miriam F. Moffatt,Moisés Selman,Annie Pardo,Dong Soon Kim,James D. Crapo,Barry J. Make,Elizabeth A. Regan,Dinesha Walek,Jerry Daniel,Yoichiro Kamatani,Diana Zelenika,Keith P Smith,David McKean,Brent S. Pedersen,Janet Talbert,Ravin N. Kidd,Cheryl Markin,Kenneth B. Beckman,Mark Lathrop,Mark Lathrop,Marvin I. Schwarz,David A. Schwartz +50 more
TL;DR: The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Journal ArticleDOI
Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis
Anna L. Peljto,Yingze Zhang,Tasha E. Fingerlin,Shwu-Fan Ma,Joe G.N. Garcia,Thomas J. Richards,Lori J. Silveira,Kathleen O. Lindell,Mark P. Steele,James E. Loyd,Kevin F. Gibson,Max A. Seibold,Kevin K. Brown,Janet Talbert,Cheryl Markin,Karl Kossen,Scott D. Seiwert,Elissa Murphy,Imre Noth,Marvin I. Schwarz,Naftali Kaminski,David A. Schwartz +21 more
TL;DR: Whether the MUC5B promoter polymorphism (rs35705950), previously reported to be associated with the development of pulmonary fibrosis, is associated with survival in IPF is investigated to determine.
Journal ArticleDOI
Clinical and pathologic features of familial interstitial pneumonia.
Mark P. Steele,Marcy C. Speer,James E. Loyd,Kevin K. Brown,Aretha Herron,Susan H. Slifer,Lauranell H. Burch,Momen M. Wahidi,John A. Phillips,Thomas A. Sporn,H. Page McAdams,Marvin I. Schwarz,David A. Schwartz +12 more
TL;DR: It is suggested that FIP may be caused by an interaction between a specific environmental exposure and a gene (or genes) that predisposes to the development of several subtypes of idiopathic interstitial pneumonia.
Journal ArticleDOI
MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities
Gary M. Hunninghake,Hiroto Hatabu,Yuka Okajima,Wei Gao,Josée Dupuis,Jeanne C. Latourelle,Mizuki Nishino,Tetsuro Araki,Oscar E. Zazueta,Sila Kurugol,James C. Ross,Raúl San José Estépar,Elissa Murphy,Mark P. Steele,James E. Loyd,Marvin I. Schwarz,Tasha E. Fingerlin,Ivan O. Rosas,George R. Washko,George T. O'Connor,David A. Schwartz +20 more
TL;DR: The MUC5B promoter polymorphism was found to be associated with interstitial lung disease in the general population, although this association was more apparent in older persons, it did not appear to be influenced by cigarette smoking.