C
Christophe Caux
Researcher at French Institute of Health and Medical Research
Publications - 254
Citations - 32907
Christophe Caux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 74, co-authored 232 publications receiving 30760 citations. Previous affiliations of Christophe Caux include Centre national de la recherche scientifique & International Facility Management Association.
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Journal ArticleDOI
Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
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GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
TL;DR: It is demonstrated that cooperation between GM-CSF and tumour necrosis factor-α (TNF-α) is crucial for the generation of human dendritic/Langerhans cells from CD34+ haematopoietic progenitors.
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Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites
Marie-Caroline Dieu,Béatrice Vanbervliet,Alain Vicari,J M Bridon,Elisabeth Oldham,Smina Ait-Yahia,Francine Brière,Albert Zlotnik,Serge Lebecque,Christophe Caux +9 more
TL;DR: The observation that CCR6 mRNA expression decreases progressively as DCs mature, whereas CCR7 mRNA expression is sharply upregulated, provides a likely explanation for the changes in chemokine responsiveness, and suggests a role for MIP-3α/CCR6 in recruitment of immature DCs at site of injury and for Mip-3β/CCr7 in accumulation of antigen-loaded mature DCs in T cell–rich areas.
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Activation of human dendritic cells through CD40 cross-linking.
Christophe Caux,Catherine Massacrier,Béatrice Vanbervliet,Bertrand Dubois,C. van Kooten,Isabelle Durand,Jacques Banchereau +6 more
TL;DR: It is demonstrated that dendritic Langerhans cells (D-Lc) generated by culturing cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating and tumor necrosis factor alpha (TNF-alpha) express functional CD40 at a density higher than that found on B cells.
Journal ArticleDOI
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.
Christophe Caux,Béatrice Vanbervliet,Catherine Massacrier,Colette Dezutter-Dambuyant,B de Saint-Vis,C Jacquet,K Yoneda,Sadao Imamura,Daniel Schmitt,Jacques Banchereau +9 more
TL;DR: The present study demonstrates that cord blood CD34+ HPC indeed differentiate along two independent DC pathways, and demonstrates that different pathways of DC development exist: the Langerhans cells and the CD14(+)-derived DC related to dermal DC or circulating blood DC.