C
Christopher A. Baker
Researcher at Allen Institute for Brain Science
Publications - 40
Citations - 2043
Christopher A. Baker is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Medicine & Chylomicron. The author has an hindex of 16, co-authored 34 publications receiving 1527 citations. Previous affiliations of Christopher A. Baker include Scripps Research Institute & Max Planck Society.
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Journal ArticleDOI
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Tanya L. Daigle,Linda Madisen,Travis A. Hage,Matthew T. Valley,Ulf Knoblich,Rylan S. Larsen,Marc Takeno,Lawrence Huang,Hong Gu,Rachael Larsen,Maya Mills,Alice Bosma-Moody,La'Akea Siverts,Miranda Walker,Lucas T. Graybuck,Zizhen Yao,Olivia Fong,Thuc Nghi Nguyen,Emma Garren,Garreck H. Lenz,Mariya Chavarha,Julie Pendergraft,James Harrington,Karla E. Hirokawa,Julie A. Harris,Philip R. Nicovich,Medea McGraw,Douglas R. Ollerenshaw,Kimberly A. Smith,Christopher A. Baker,Jonathan T. Ting,Susan M. Sunkin,Jérôme Lecoq,Michael Z. Lin,Edward S. Boyden,Gabe J. Murphy,Nuno Maçarico da Costa,Jack Waters,Lu Li,Bosiljka Tasic,Hongkui Zeng +40 more
TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools.
Journal ArticleDOI
Prion strain discrimination in cell culture: the cell panel assay.
Sukhvir P. Mahal,Christopher A. Baker,Cheryl A. Demczyk,Emery Smith,Christian Julius,Charles Weissmann +5 more
TL;DR: It is reported that a cloned murine neuroblastoma cell population, N2a-PK1, is highly heterogeneous in regard to its susceptibility to RML and 22L prions, indicating that the responses can vary independently.
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Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease
TL;DR: For example, this paper analyzed RNA from isolated microglia with relevant cDNA arrays, and identified ≈30 transcripts not previously examined in any transmissible spongiform encephalopathy.
Journal ArticleDOI
Two-Photon Bidirectional Control and Imaging of Neuronal Excitability with High Spatial Resolution In Vivo
Angelo Forli,Dania Vecchia,Noemi Binini,Francesca Succol,Serena Bovetti,Claudio Moretti,Francesco Nespoli,Mathias Mahn,Christopher A. Baker,M. McLean Bolton,Ofer Yizhar,Tommaso Fellin +11 more
TL;DR: Efficient control of neural excitability across cell types and layers with holographic stimulation and improved spatial resolution by opsin somatic targeting is demonstrated and represents a powerful tool to causally dissect how activity patterns in specified ensembles of neurons determine brain function and animal behavior.
Journal ArticleDOI
Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin.
TL;DR: Refinement in optogenetic methods for circuit mapping that enable measurements of functional synaptic connectivity with single-neuron resolution are described, able to reliably evoke action potentials in individual neurons.