L
Lawrence Huang
Researcher at Allen Institute for Brain Science
Publications - 18
Citations - 1346
Lawrence Huang is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Calcium imaging & Visual cortex. The author has an hindex of 12, co-authored 17 publications receiving 878 citations. Previous affiliations of Lawrence Huang include University of California, San Francisco & University of Virginia.
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Journal ArticleDOI
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Tanya L. Daigle,Linda Madisen,Travis A. Hage,Matthew T. Valley,Ulf Knoblich,Rylan S. Larsen,Marc Takeno,Lawrence Huang,Hong Gu,Rachael Larsen,Maya Mills,Alice Bosma-Moody,La'Akea Siverts,Miranda Walker,Lucas T. Graybuck,Zizhen Yao,Olivia Fong,Thuc Nghi Nguyen,Emma Garren,Garreck H. Lenz,Mariya Chavarha,Julie Pendergraft,James Harrington,Karla E. Hirokawa,Julie A. Harris,Philip R. Nicovich,Medea McGraw,Douglas R. Ollerenshaw,Kimberly A. Smith,Christopher A. Baker,Jonathan T. Ting,Susan M. Sunkin,Jérôme Lecoq,Michael Z. Lin,Edward S. Boyden,Gabe J. Murphy,Nuno Maçarico da Costa,Jack Waters,Lu Li,Bosiljka Tasic,Hongkui Zeng +40 more
TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools.
Journal ArticleDOI
A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex
Saskia E. J. de Vries,Jérôme Lecoq,Michael A. Buice,Peter A. Groblewski,Gabriel Koch Ocker,Michael Oliver,David Feng,Nicholas Cain,Peter Ledochowitsch,Daniel Millman,Kate Roll,Marina Garrett,Tom Keenan,Leonard Kuan,Stefan Mihalas,Shawn R. Olsen,Carol L. Thompson,Wayne Wakeman,Jack Waters,Derric Williams,Chris Barber,Nathan Berbesque,Brandon Blanchard,Nicholas Bowles,Shiella Caldejon,Linzy Casal,Andrew Cho,Sissy Cross,Chinh Dang,Tim A. Dolbeare,Melise Edwards,John Galbraith,Nathalie Gaudreault,Terri L. Gilbert,Fiona Griffin,Perry Hargrave,Robert Howard,Lawrence Huang,Sean Jewell,Nika H. Keller,Ulf Knoblich,Josh D Larkin,Rachael Larsen,Chris Lau,Eric Lee,Felix Lee,Arielle Leon,Lu Li,Fuhui Long,Jennifer Luviano,Kyla Mace,Thuyanh V. Nguyen,Jed Perkins,Miranda Robertson,Sam Seid,Eric Shea-Brown,Eric Shea-Brown,Jianghong Shi,Nathan Sjoquist,Cliff Slaughterbeck,David Sullivan,Ryan Valenza,White C,Ali Williford,Daniela Witten,Jun Zhuang,Hongkui Zeng,Colin Farrell,Lydia Ng,Amy Bernard,John W. Phillips,R. Clay Reid,Christof Koch +72 more
TL;DR: An open, large-scale physiological survey of activity in the awake mouse visual cortex: the Allen Brain Observatory Visual Coding dataset is reported, revealing response specializations within the mouseVisual cortex.
Posted ContentDOI
A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex
de Vries Sej,Jérôme Lecoq,Michael A. Buice,Peter A. Groblewski,Gabriel Koch Ocker,Michael Oliver,David Feng,Nicholas Cain,Peter Ledochowitsch,Daniel Millman,Kate Roll,Marina Garrett,Tom Keenan,Leonard Kuan,Stefan Mihalas,Shawn R. Olsen,Carol L. Thompson,Wayne Wakeman,Jack Waters,Derric Williams,Chris Barber,Nathan Berbesque,Brandon Blanchard,Bowles N,Shiella Caldejon,Linzy Casal,Cho A,Sissy Cross,Chinh Dang,Tim A. Dolbeare,Edwards M,John Galbraith,Nathalie Gaudreault,Fiona Griffin,Hargrave P,Robert Howard,Lawrence Huang,Sean Jewell,Nika H. Keller,Ulf Knoblich,Josh D Larkin,Rachael Larsen,Chris Lau,Eric Lee,Felix Lee,Arielle Leon,Lei Li,Fuhui Long,Jennifer Luviano,Kyla Mace,Thuyanh V. Nguyen,Jed Perkins,Miranda Robertson,Sam Seid,Eric Shea-Brown,Jingyi Shi,Nathan Sjoquist,Clifford R. Slaughterbeck,David Sullivan,Ryan Valenza,White C,Ali Williford,Daniela Witten,Jun Zhuang,Hongkui Zeng,Colin Farrell,Lindsay Ng,Amy Bernard,John W. Phillips,Robert Reid,Christof Koch +70 more
TL;DR: An open, large-scale physiological survey of neural activity in the awake mouse visual cortex: the Allen Brain Observatory Visual Coding dataset is reported, revealing functional differences across these dimensions and showing that visual cortical responses are sparse but correlated.
Journal ArticleDOI
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice.
Lawrence Huang,Peter Ledochowitsch,Ulf Knoblich,Jérôme Lecoq,Gabe J. Murphy,R. Clay Reid,Saskia E. J. de Vries,Christof Koch,Hongkui Zeng,Michael A. Buice,Jack Waters,Lu Li,Lu Li +12 more
TL;DR: Huang et al. as discussed by the authors used mice that had been genetically modified to produce a calcium indicator in neurons of the visual cortex and simultaneously obtained both fluorescence measurements and electrical recordings from these neurons.
Journal ArticleDOI
Rho Kinase Regulates the Intracellular Micromechanical Response of Adherent Cells to Rho Activation
TL;DR: It is observed that the cytoplasmic stiffness and viscosity of serum-starved Swiss 3T3 cells transiently and locally enhances upon treatment with lysophosphatidic acid, and this mechanical behavior follows a trend similar to Rho activity, which suggests a critical role for Rho kinase in the regulation of intracellular mechanics.