C
Christopher B. Heward
Researcher at Translational Genomics Research Institute
Publications - 11
Citations - 2307
Christopher B. Heward is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 8, co-authored 11 publications receiving 2195 citations.
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Journal ArticleDOI
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
Keith D. Coon,Amanda J. Myers,David Craig,Jennifer Webster,John V. Pearson,Diane Hu Lince,Victoria Zismann,Thomas G. Beach,Doris G. Leung,Leslie Bryden,Rebecca F. Halperin,Lauren Marlowe,Mona Kaleem,Douglas G. Walker,Rivka Ravid,Christopher B. Heward,Joseph Rogers,Andreas Papassotiropoulos,Andreas Papassotiropoulos,Eric M. Reiman,John Hardy,Dietrich A. Stephan +21 more
TL;DR: This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in thehuman genome.
Journal ArticleDOI
A survey of genetic human cortical gene expression.
Amanda J. Myers,Amanda J. Myers,J. Raphael Gibbs,Jennifer Webster,Kristen Rohrer,Alice Zhao,Lauren Marlowe,Mona Kaleem,Doris G. Leung,Leslie Bryden,Priti Nath,Victoria Zismann,Keta Joshipura,Matthew J. Huentelman,Diane Hu-Lince,Keith D. Coon,Keith D. Coon,David Craig,John V. Pearson,Peter Holmans,Christopher B. Heward,Eric M. Reiman,Dietrich A. Stephan,John Hardy +23 more
TL;DR: This work has carried out whole-genome genotyping and expression analysis on a series of 193 neuropathologically normal human brain samples using the Affymetrix GeneChip Human Mapping 500K Array Set and Illumina HumanRefseq-8 Expression BeadChip platforms and presents data showing that 58% of the transcriptome is cortically expressed in at least 5% of the authors' samples and that of these cortically expression transcripts, 21% have expression profiles that correlate with their genotype.
Journal ArticleDOI
GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers
Eric M. Reiman,Jennifer Webster,Amanda J. Myers,Amanda J. Myers,John Hardy,John Hardy,Travis Dunckley,Victoria Zismann,Keta Joshipura,John V. Pearson,Diane Hu-Lince,Matthew J. Huentelman,David Craig,Keith D. Coon,Keith D. Coon,Winnie S. Liang,Ri Lee H. Herbert,Thomas G. Beach,Kristen Rohrer,Alice S. Zhao,Doris G. Leung,Leslie Bryden,Lauren Marlowe,Mona Kaleem,Diego Mastroeni,Andrew Grover,Christopher B. Heward,Rivka Ravid,Joseph Rogers,Mike Hutton,Stacey Melquist,R. C. Petersen,Gene E. Alexander,Richard J. Caselli,Walter A. Kukull,Andreas Papassotiropoulos,Andreas Papassotiropoulos,Dietrich A. Stephan +37 more
TL;DR: The findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology.
Journal ArticleDOI
Genetic Control of Human Brain Transcript Expression in Alzheimer Disease
Jennifer Webster,Jennifer Webster,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer Clarke,Monika Ray,Weixiong Zhang,Peter Holmans,Kristen Rohrer,Alice Zhao,Lauren Marlowe,Mona Kaleem,Donald S. McCorquodale,Cindy Cuello,Doris G. Leung,Leslie Bryden,Priti Nath,Victoria Zismann,Keta Joshipura,Matthew J. Huentelman,Diane Hu-Lince,Keith D. Coon,Keith D. Coon,David Craig,John V. Pearson,Christopher B. Heward,Eric M. Reiman,Dietrich A. Stephan,John Hardy,John Hardy,Amanda J. Myers,Amanda J. Myers +31 more
TL;DR: This study shows how the relationship between common inherited genetic variants and brain transcript expression can be used in the study of human brain disorders and suggests that studying the transcriptome as a quantitative endo-phenotype has greater power for discovering risk SNPs influencing expression than the use of discrete diagnostic categories.
Journal ArticleDOI
Association of CR1, CLU, and PICALM with Alzheimer’s disease in a cohort of clinically characterized and neuropathologically verified individuals
Jason J. Corneveaux,Amanda J. Myers,April N. Allen,Jeremy J. Pruzin,Manuel Ramirez,Anzhelika Engel,Mike A. Nalls,Kewei Chen,Wendy Lee,Kendria Chewning,Stephen Villa,Hunsar B. Meechoovet,Jill D. Gerber,Danielle Frost,Hollie Benson,Sean O'Reilly,Lori B. Chibnik,Joshua M. Shulman,Andrew B. Singleton,David Craig,Kendall Van Keuren-Jensen,Travis Dunckley,David A. Bennett,Philip L. De Jager,Christopher B. Heward,John Hardy,Eric M. Reiman,Matthew J. Huentelman +27 more
TL;DR: Assessment of the most replicated genetic associations for Alzheimer's disease using data generated on Affymetrix SNP 6.0 arrays confirms the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs.