K
Keta Joshipura
Researcher at Translational Genomics Research Institute
Publications - 10
Citations - 1754
Keta Joshipura is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 8, co-authored 10 publications receiving 1685 citations.
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Journal ArticleDOI
A survey of genetic human cortical gene expression.
Amanda J. Myers,Amanda J. Myers,J. Raphael Gibbs,Jennifer Webster,Kristen Rohrer,Alice Zhao,Lauren Marlowe,Mona Kaleem,Doris G. Leung,Leslie Bryden,Priti Nath,Victoria Zismann,Keta Joshipura,Matthew J. Huentelman,Diane Hu-Lince,Keith D. Coon,Keith D. Coon,David Craig,John V. Pearson,Peter Holmans,Christopher B. Heward,Eric M. Reiman,Dietrich A. Stephan,John Hardy +23 more
TL;DR: This work has carried out whole-genome genotyping and expression analysis on a series of 193 neuropathologically normal human brain samples using the Affymetrix GeneChip Human Mapping 500K Array Set and Illumina HumanRefseq-8 Expression BeadChip platforms and presents data showing that 58% of the transcriptome is cortically expressed in at least 5% of the authors' samples and that of these cortically expression transcripts, 21% have expression profiles that correlate with their genotype.
Journal ArticleDOI
GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers
Eric M. Reiman,Jennifer Webster,Amanda J. Myers,Amanda J. Myers,John Hardy,John Hardy,Travis Dunckley,Victoria Zismann,Keta Joshipura,John V. Pearson,Diane Hu-Lince,Matthew J. Huentelman,David Craig,Keith D. Coon,Keith D. Coon,Winnie S. Liang,Ri Lee H. Herbert,Thomas G. Beach,Kristen Rohrer,Alice S. Zhao,Doris G. Leung,Leslie Bryden,Lauren Marlowe,Mona Kaleem,Diego Mastroeni,Andrew Grover,Christopher B. Heward,Rivka Ravid,Joseph Rogers,Mike Hutton,Stacey Melquist,R. C. Petersen,Gene E. Alexander,Richard J. Caselli,Walter A. Kukull,Andreas Papassotiropoulos,Andreas Papassotiropoulos,Dietrich A. Stephan +37 more
TL;DR: The findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology.
Journal ArticleDOI
Genetic Control of Human Brain Transcript Expression in Alzheimer Disease
Jennifer Webster,Jennifer Webster,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer Clarke,Monika Ray,Weixiong Zhang,Peter Holmans,Kristen Rohrer,Alice Zhao,Lauren Marlowe,Mona Kaleem,Donald S. McCorquodale,Cindy Cuello,Doris G. Leung,Leslie Bryden,Priti Nath,Victoria Zismann,Keta Joshipura,Matthew J. Huentelman,Diane Hu-Lince,Keith D. Coon,Keith D. Coon,David Craig,John V. Pearson,Christopher B. Heward,Eric M. Reiman,Dietrich A. Stephan,John Hardy,John Hardy,Amanda J. Myers,Amanda J. Myers +31 more
TL;DR: This study shows how the relationship between common inherited genetic variants and brain transcript expression can be used in the study of human brain disorders and suggests that studying the transcriptome as a quantitative endo-phenotype has greater power for discovering risk SNPs influencing expression than the use of discrete diagnostic categories.
Journal ArticleDOI
Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis
Travis Dunckley,Matthew J. Huentelman,David Craig,John V. Pearson,Szabolcs Szelinger,Keta Joshipura,Rebecca F. Halperin,Chelsea Stamper,Kendall Jensen,David Letizia,Sharon E. Hesterlee,Alan Pestronk,Todd Levine,Tulio E. Bertorini,Michael C. Graves,Tahseen Mozaffar,Carlayne E. Jackson,Peter Bosch,April McVey,Arthur Dick,Richard J. Barohn,Catherine Lomen-Hoerth,Jeffrey Rosenfeld,Daniel T. O'Connor,Kuixing Zhang,Richard Crook,Henrik Ryberg,Mike Hutton,Jonathan S. Katz,Ericka Simpson,Hiroshi Mitsumoto,Robert Bowser,Robert G. Miller,Stanley H. Appel,Dietrich A. Stephan +34 more
TL;DR: Variants of FLJ10986 may confer susceptibility to sporadic ALS and 50 other candidate loci warrant further investigation for their potential role in conferring susceptibility to the disease.
Journal ArticleDOI
Evidence for an association between KIBRA and late-onset Alzheimer's disease.
Jason J. Corneveaux,Winnie S. Liang,Eric M. Reiman,Jennifer Webster,Amanda J. Myers,Amanda J. Myers,Victoria Zismann,Keta Joshipura,John V. Pearson,Diane Hu-Lince,David Craig,Keith D. Coon,Keith D. Coon,Travis Dunckley,Daniel Bandy,Wendy Lee,Kewei Chen,Thomas G. Beach,Diego Mastroeni,Andrew Grover,Rivka Ravid,Sigrid Botne Sando,Jan O. Aasly,Reinhard Heun,Frank Jessen,Heike Kölsch,Joseph G. Rogers,Mike Hutton,Stacey Melquist,Stacey Melquist,R. C. Petersen,Gene E. Alexander,Richard J. Caselli,Andreas Papassotiropoulos,Andreas Papassotiropoulos,Dietrich A. Stephan,Matthew J. Huentelman +36 more
TL;DR: KIBRA is associated with both individual variation in normal episodic memory and predisposition to AD, and non-carriers of the KIBRA T-allele had increased risk of late-onset AD.