C
Christopher B. Newgard
Researcher at Duke University
Publications - 483
Citations - 55811
Christopher B. Newgard is an academic researcher from Duke University. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 111, co-authored 460 publications receiving 49018 citations. Previous affiliations of Christopher B. Newgard include Durham University & University of Texas at Austin.
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Journal ArticleDOI
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Vanessa K. Ridaura,Jeremiah J. Faith,Federico E. Rey,Jiye Cheng,Alexis E. Duncan,Andrew L. Kau,Nicholas W. Griffin,Vincent Lombard,Bernard Henrissat,Bernard Henrissat,James R. Bain,Michael J. Muehlbauer,Olga Ilkayeva,Clay F. Semenkovich,Katsuhiko Funai,David K. Hayashi,Barbara J. Lyle,Margaret C. Martini,Luke K. Ursell,Jose C. Clemente,Will Van Treuren,William A. Walters,Rob Knight,Rob Knight,Christopher B. Newgard,Andrew C. Heath,Jeffrey I. Gordon +26 more
TL;DR: The results reveal that transmissible and modifiable interactions between diet and microbiota influence host biology and that adiposity is transmissible from human to mouse and that it was associated with changes in serum levels of branched-chain amino acids.
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A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
Christopher B. Newgard,Jie An,James R. Bain,Michael J. Muehlbauer,Robert Stevens,Lillian F. Lien,Andrea M. Haqq,Svati H. Shah,Michelle Arlotto,Cris A. Slentz,James Rochon,Dianne Gallup,Olga Ilkayeva,Brett R. Wenner,William S. Yancy,Howard Eisenson,Gerald Musante,Richard S. Surwit,David S. Millington,Mark D. Butler,Laura P. Svetkey +20 more
TL;DR: Findings show that in the context of a dietary pattern that includes high fat consumption, BCAA contributes to development of obesity-associated insulin resistance.
Journal ArticleDOI
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
J. Cliff Yoon,Pere Puigserver,Guoxun Chen,Jerry Donovan,Zhidan Wu,James Rhee,Guillaume Adelmant,John M. Stafford,C. Ronald Kahn,Daryl K. Granner,Christopher B. Newgard,Bruce M. Spiegelman +11 more
TL;DR: The results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin–cAMP axis in liver.
Journal ArticleDOI
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Timothy R. Koves,John R. Ussher,Robert C. Noland,Dorothy H. Slentz,Merrie Mosedale,Olga Ilkayeva,James R. Bain,Robert Stevens,Jason R.B. Dyck,Christopher B. Newgard,Gary D. Lopaschuk,Deborah M. Muoio +11 more
TL;DR: Target metabolomics finds that obesity-related insulin resistance in skeletal muscle is characterized by excessive beta-oxidation, impaired switching to carbohydrate substrate during the fasted-to-fed transition, and coincident depletion of organic acid intermediates of the tricarboxylic acid cycle.
Journal ArticleDOI
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey,Tadahiro Shimazu,Tadahiro Shimazu,Eric S. Goetzman,Enxuan Jing,Bjoern Schwer,Bjoern Schwer,Bjoern Schwer,David B. Lombard,Carrie A. Grueter,Charles A. Harris,Sudha B. Biddinger,Olga Ilkayeva,Robert Stevens,Yu Li,Asish K. Saha,Neil B. Ruderman,James R. Bain,Christopher B. Newgard,Robert V. Farese,Frederick W. Alt,C. Ronald Kahn,Eric Verdin,Eric Verdin +23 more
TL;DR: It is demonstrated that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting and acetylation is identified as a novel regulatory mechanism for mitochondrial fatty- acid oxidation.