C
Christopher Gu
Researcher at Harvard University
Publications - 13
Citations - 860
Christopher Gu is an academic researcher from Harvard University. The author has contributed to research in topics: Gp41 & Trimer. The author has an hindex of 10, co-authored 13 publications receiving 750 citations.
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Journal ArticleDOI
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
Youdong Mao,Liping Wang,Christopher Gu,Alon Herschhorn,Shi Hua Xiang,Hillel Haim,Xinzhen Yang,Joseph Sodroski,Joseph Sodroski +8 more
TL;DR: An ~11-Å cryo-EM structure of the trimeric HIV-1 Env precursor in its unliganded state is described, which consists of a cage-like structure with an interior void surrounding the trimer axis and restricts antibody access.
Journal ArticleDOI
Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.
Alon Herschhorn,Xiaochu Ma,Christopher Gu,John D. Ventura,Luis R. Castillo-Menendez,Bruno Melillo,Daniel S. Terry,Amos B. Smith,Scott C. Blanchard,James B. Munro,Walther Mothes,Andrés Finzi,Joseph Sodroski +12 more
TL;DR: Increased sampling of state 2 is an Env conformation on the virus entry pathway enhances the ability of HIV-1 to infect cells that express low levels of the CD4 receptor and allows the virus to evade neutralizing antibodies and small-molecule inhibitors.
Journal ArticleDOI
Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140
Eden P. Go,Alon Herschhorn,Christopher Gu,Luis R. Castillo-Menendez,Shijian Zhang,Youdong Mao,Haiyan Chen,Haitao Ding,John K. Wakefield,David Hua,Hua-Xin Liao,John C. Kappes,John C. Kappes,Joseph Sodroski,Heather Desaire +14 more
TL;DR: Exogenous membrane-anchored Envs, which can be produced in large quantities in mammalian cells, also display a virion-like glycan profile, where the glycoprotein is extensively decorated with high-mannose glycans, a carbohydrate profile that would be desirable to mimic with a vaccine.
Journal ArticleDOI
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer
Youdong Mao,Liping Wang,Christopher Gu,Alon Herschhorn,Anik Désormeaux,Andrés Finzi,Shi Hua Xiang,Joseph Sodroski +7 more
TL;DR: The Env trimer architecture provides mechanistic insights into the metastability of the unliganded state, receptor-induced conformational changes, and quaternary structure-based strategies for immune evasion.
Journal ArticleDOI
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.
Alon Herschhorn,Christopher Gu,Francesca Moraca,Xiaochu Ma,Mark Farrell,Amos B. Smith,Marie Pancera,Peter D. Kwong,Arne Schön,Ernesto Freire,Cameron F. Abrams,Scott C. Blanchard,Walther Mothes,Joseph Sodroski +13 more
TL;DR: Develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions, providing insights into the molecular mechanism and vulnerability of HIV-1 entry.