Haitao Ding

TL;DR: It is suggested that the acquisition of clinical HIV-1 subtype B infection occurs by mucosal exposure to virus that is not highly macrophage tropic and that the generation and initial biological characterization of 10 clade B T/F infectious molecular clones provides new opportunities to probe virus-host interactions involved in HIV- 1 transmission.

TL;DR: The establishment of systemic HIV-1 infection by relatively IFN α-resistant founder viruses lends strong support to the hypothesis that IFNα plays an important role in the control of HIV- 1 replication during the earliest stages of infection, prior to systemic viral spread.

TL;DR: HIV-1 neutralization, targeting TZM-bl cells, was highly correlative comparing virus (LucR) and cell (firefly luciferase) readouts, representing advancement toward a standardizable PBMC-based neutralization assay for assessing HIV-1 vaccine immunogen efficacy.

TL;DR: It is found that T/F and chronic control Envs were indistinguishable in the efficiency with which they used CD4 and CCR5, and saturating concentrations of anti-α4β7 antibodies failed to inhibit infection and replication of T/f as well as chronic control viruses.

TL;DR: Exogenous membrane-anchored Envs, which can be produced in large quantities in mammalian cells, also display a virion-like glycan profile, where the glycoprotein is extensively decorated with high-mannose glycans, a carbohydrate profile that would be desirable to mimic with a vaccine.