C
Christopher R. Vakoc
Researcher at Cold Spring Harbor Laboratory
Publications - 153
Citations - 21315
Christopher R. Vakoc is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 52, co-authored 132 publications receiving 17071 citations. Previous affiliations of Christopher R. Vakoc include University of Pennsylvania & Watson School of Biological Sciences.
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Journal ArticleDOI
RIOK1 kinase activity is required for cell survival irrespective of MTAP status.
Alexandra Hörmann,Barbara Hopfgartner,Thomas Köcher,Maja Corcokovic,Teresa Krammer,Christoph Reiser,Gerd Bader,Junwei Shi,Katharina Ehrenhöfer,Simon Wöhrle,Norbert Schweifer,Christopher R. Vakoc,Norbert Kraut,Mark Pearson,Mark Petronczki,Ralph A. Neumüller +15 more
TL;DR: It is revealed that the kinase activity of R IOK1 is required for the survival of cancer cell lines irrespective of their MTAP status and cast doubt on the therapeutic exploitability of RIOK1 in the context of MTAP-deleted cancers.
Journal ArticleDOI
Preclinical rationale for entinostat in embryonal rhabdomyosarcoma.
Narendra Bharathy,Noah E. Berlow,Eric Wang,Jinu Abraham,Teagan P. Settelmeyer,Jody E. Hooper,Matthew N. Svalina,Zia Bajwa,Martin Goros,Brian Hernandez,Johannes E. A. Wolff,Ranadip Pal,Angela M Davies,Arya Ashok,Darnell Bushby,Maria Cecilia Mancini,Christopher J. Noakes,Neal Goodwin,Peter Ordentlich,James G. Keck,Douglas S. Hawkins,Erin R. Rudzinski,Atiya Mansoor,Theodore J. Perkins,Theodore J. Perkins,Christopher R. Vakoc,Joel E. Michalek,Charles Keller +27 more
TL;DR: ENT in combination with the chemotherapy VCR has synergistic antitumor activity in a subset of fusion-negative eRMS in orthotopic “allografts,” although PDX mouse models were too hypersensitive to the VCR dose used to detect synergy.
Journal ArticleDOI
The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure.
Hsiang-Chen Chou,Hsiang-Chen Chou,Kuhulika Bhalla,Osama El Demerdesh,Olaf Klingbeil,Kaarina Hanington,Sergey Aganezov,Peter Andrews,Habeeb Alsudani,Kenneth Chang,Christopher R. Vakoc,Michael C. Schatz,W. Richard McCombie,Bruce Stillman +13 more
TL;DR: The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication as mentioned in this paper.
Journal ArticleDOI
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Zhaolin Yang,Xiaoli S. Wu,Xiaoli S. Wu,Yiliang Wei,Sofya A. Polyanskaya,Shruti V. Iyer,Shruti V. Iyer,Moonjung Jung,Francis P. Lach,Emmalee R. Adelman,Olaf Klingbeil,Joseph P. Milazzo,Melissa Kramer,Osama El Demerdash,Kenneth Chang,Sara Goodwin,Emily Hodges,W. Richard McCombie,Maria E. Figueroa,Agata Smogorzewska,Christopher R. Vakoc +20 more
TL;DR: In this article, the essentiality of the ubiquitination machinery in cancer cell lines using domain-focused CRISPR screening was identified, which revealed Fanconi anemia (FA) proteins UBE2T and FANCL as unique dependencies in acute myeloid leukemia (AML).
Posted ContentDOI
The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure.
Hsiang-Chen Chou,Hsiang-Chen Chou,Kuhulika Bhalla,Osama El Demerdesh,Olaf Klingbeil,Kaarina Hanington,Sergey Aganezov,Peter Andrews,Habeeb Alsudani,Kenneth Chang,Christopher R. Vakoc,Michael C. Schatz,W. Richard McCombie,Bruce Stillman +13 more
TL;DR: Tiling-sgRNA CRISPR screens are reported that show that each subunit of ORC and CDC6 are essential in human cells, and are indispensable for normal cellular proliferation and contribute to nuclear organization.